217 



- 1 9 5 - 



When foreign protein therapy induces a refractory condition, 

 the use of ACTH or cortisone is advised; the adrenalcortical 

 factors are useful when pyrogenic therapy no longer produces 

 eoslnopenia or must be prolonged for longer than one week. 



621. ASHENBURG, N. J., SANDHOLZER, L. A., SCHERP, H. W.^and BERRY, G.P. 



The inhibition of bacteriophagy by bacterial and nonbacterial 

 polysaccharides 



J. Eact. 59:^81-687, 1950 



Relationships between polysaccharide and bacteriophage resemble 

 those existing between antigen and antibody, the former existing 

 as a surface antigen and inhibiting lytic action. Nonspecific 

 inhibition has been credited to starches, glycogen and gums. In 

 this study the effect of nonbacterial polysaccharides and those 

 obtained from capsules of Aerobacter and Klebsiella was to in- 

 hibit the lytic action of Friedlander Haclllus bacteriophage. 

 All exhibited this activity, but inhibition was not complete; 

 it varied with the polysaccharide used and the host organism. 



622. BECK, L. V. and VOLOSHIN, T. 



Influence of adrenal hormones on toxic and tumor-damaging effects 

 of certain substances 



A. J. Physiol, 163:696-697, 1950 (Abstract) 



Cortisone and adrenal extract may counteract the damage wrought 

 by tumor-necrotizlng substances on sarcoma #37. Mice injected 

 either intraperitoneally or subcutaneously with cortisone ex- 

 hibited increased tolerance for arsenite administered one hour 

 later by either intravenous or subcutaneous routes. When adrenal 

 extract was injected peritoneally, there was an increased toler- 

 ance for both arsenite and mapharsen, and some protection against 

 arsenite could be secured by previous Injection of ACTH. The 

 increase in tolerance was greater in the male and at the L5 level. 

 Cortisone or adrenal extract, when administered before intra- 

 peritoneal Injections of the tumor-necrotlzlng polysaccharide of 

 S. marcescens , increased tolerance, and cortisone also afforded 

 some protection against the Intravenously injected polysaccharide. 

 Protective patterns differed fromthose invoked against arsenlcals. 

 The adrenocortical factors do not protect mice against lethal 

 or sublethal amounts of alpha peltatln or acrldines. 



623. BENNETT, I. L., JR „ , and BEESON, P. B. 



The properties and biologic effects of bacterial pyrogens 



