218 



- 1 9 5 - 



Medicine 29:365-^00, I95O 



In a comprehensive survey of the literature of pyrogenic 

 substances extending from I855 to the present day^ the bacter- 

 iology, physical characteristics and chemical properties of 

 these substances are outlined and discussed. In turn, the 

 application of pyrogens to therapeutic uses and physiologic re- 

 sponse to their administration are outlined in detail. "The 

 role of pyrogens in disease is still Incompletely understood." 

 A bibliography containing 246 references is appended. 



624. BERGSMAN, A. and HEDENIUS, P. 



De pyrogena substansernas betydelse via parentcralt bruk av 

 vltskor (Problem of pyrogens in the use of parenteral solutions) 



Nord Med. ^3: 672-676, I95O 



625. BLICKENSTAFF, D. and GROSSMAN, M. I. 



A quantitative study of the reduction of gastric acid secretion 

 associated with pyrexia 



Am. J. Physiol. 160:567-571^ 1950 



Pyrexia produced by Intravenous pyrexin or bactei-lal pyrogen 

 was not directly responsible for inhibition of secretory activity 

 in the dog. PYROMEN, prepared from cultures of Ps. aeruginosa, 

 in doses ranging from 0.5 microgram per kg. to 10.0, and pyrexin, 

 from sterile pleural exudate, 2 tc 30 rag. were administered to 

 'gastric pouch' dogs and secretions were collected for three or 

 more hours thereafter, A preliminary injection of histamine, 

 0.0125 mg. subcutaneously, was repeated at frequent intervals 

 throughout the test. In no test was there depression of se- 

 cretion without a rise in body temperature. When only slight 

 Increases in temperature were registered, secretion was not in- 

 hibited. However, a lag of approximately one hour between onset 

 of pyrexia and reduction of gastric secretion, as well as the 

 extension of inhibition past the period of temperature reduction, 

 would appear to rule out pyrexia as the primary agent in this 

 phenomenon. The state of hydration did not affect results. 



626. BLUMENTHAL, L- S. and FUCHS, M. 



Headache Clinics. I. What is the headache problem? 



Am. Pract. ? Digest Treat. 1:1012-1015, I95O 



Work on ACTH and PYROMEN, which appears to act in a manner slmlla? 

 to adrenal cortical derivatives, is still in the experimental 



