Ill 

 - 1 9 5 - 



stages. Proper application of PYROMEN, the antihistamines, ACTH, 

 potassium thlocyanate, banthine and dehydrogenated alkaloids of 

 ergot will be described in later publications. 



627. BOQUET, P. and IZARD, Y. 



Effect of dlbenamlne on vascular response of rabbits to typhoid 

 vaccine 



Proc. Soc. Exper.-Blol. & Med. 75:25^-259, 1950 



The Intense initial peripheral vasoconstriction produced in 

 rabbits by an injection of typhoid endotoxin was noted in 

 earlier studies. It was believed to be caused by the release 

 of adrenalin (or adrenalin-like substances) from tissues. To 

 confirm these findings, the role of adrenolytic agents in inhi- 

 biting or modifying vascular response was tested by injecting 

 0.5 to 0.8 ml. per kg. of S. typhosa endotoxin into the rabbit 

 and follov/ing this with intravenous dlbenamlne (6-10 mg. per kg.) 

 Cutaneous circulation was observed by three methods, two visual 

 and one involving the use of thermocouples. Dlbenamlne modified 

 vasoconstriction when administered either before or after the 

 endotoxin, but, for sustained effect, blocking was necessary be- 

 fore and after the vaccine. 



628. BOVE, E. 



Nogle problemer 1. pyrogenbestemmelsen (Problems of pyrogen 

 determination) 



Sven. farm, tidsskr. 5^:721-726, 1950 



629. CARLETTI, B. 



La vaccinazione aspeciflca Intradermica nella malattla di Helne- 

 Medin, Parte I. Storla, tecnlca e meccanlsmo d'azione (A specific 

 Intradermal vaccination in poliomyelitis. I. History, techniques 

 and mechanism of action) 



G. Mai. Infett. parassit (Florence) 2:l80-l87, 1950 



Intracutaneous Injection of 5OO to 5OOO million nonspecific 

 organisms in a vaccine preparation was made every 4 to 7 days 

 for 20 Injections. The treatment was often repeated 2 to 3 

 months later. The site of injection was the cutis of the lower 

 limbs, and administration was usually made at several points 

 in the area. Among the organisms present in the killed state 

 in th$ -^^accine, E, coll , Pr . vulgaris , the pyogenic streptococci. 

 Ma pyogenes and catarrhalis and , S. paratyphosa A and B are noted. 

 Seventy of 242 patients treated improved; circulation increased 

 and neuromuscular function was benefited. 



