220 



- 1 9 5 - 



630. CHARY, R. and ARDRY, R. 



Note sur le controle pyrogenique des solutions cltratees 

 utlllsees dans le transfusion sanguine (Notes on the pjrrogenic 

 control of cltrated solutions used in blood transfusion) 



Ann. blol. clin. 8:504-506, 1950 



631. CLEMENTE, CD. 



Leukocytosis in the rat upon oral administration of a bacterial 

 pyrogen 



Am. J. Physiol, 163:703, 1950 



Significant leukocytosis was observed when FYROMEN, 1 gamma 

 daily, was administered to the rat. White cell counts increased 

 from normal levels (15,000 cells per cu. mm.) to 35,000 or 

 40,000 cells per cu. mm. after 1 to 4 gammas of PYROMEN, but 

 tolerance became evident after sustained dosages at constant 

 levels, and white counts resumec normal levels. While in- 

 creased doses were ineffectual during the period when the leuko- 

 cyte count was returning to normal levels, a secondary leuko- 

 cytosis could be elicited after a rest period of 6 days; the re- 

 sponse was of shorter duration and lower intensity than the first. 

 The percentages of granular cells to the non-granular types did 

 not alter with the rising count. In only two of four animals 

 observed was leukopenia noted. In two animals, circulating 

 eosinophils showed an initial decrease but increased during the 

 leukocytosis along with other granular cells. Histologically, 

 no pathologic changes could be demonstrated in endocrine, di- 

 gestive, lymphatic or excretory organs after oral administration 

 of PYROMEN. 



632. CORELLI, P. 



L'importanza del pirogeno nella pratica medica e trasf usionale 

 (contribute alia profilassi delle reazioni da trasfusione, da 

 ipodermoclisi, fleboclisi, da endovenose di calcio, ecc.) (Im- 

 portance of pyrogen in medical transfusion practice; contribution 

 to prophylaxis, reactions due to transfusion, to hypodermoclysis, 

 to phleboclysis, to intravenous calcium, etc.) 



Pollclinico (sez. prat.) 57:345-34?, 195O 



Reactions may occur even when depyrogenated solutions are em- 

 ployed since glassware, tubes, needles, or residues of blood and 

 plasma may produce pyrogens, which after sterilization, continue 

 to act as "denatured" pyretogenic agents, A thorough cleaning 

 must precede sterilization, for elimination of possible pyrexial 

 materials. 



