222 



- 1 9 5 - 



Proc. Soc. Exp. Biol. Med, 75:661-666, 1950 



These experiments were designed to study the correlation be- 

 tween the magnitude of leukocytic and thermogenic responses to 

 pyrogen in the rabbit and the amount of pyrogen administered. 

 Vaccines from 2 strains of E. typhosa were used. Fifty-eight 

 male rabbits were divided into four groups; in each group one 

 of the following was injected intravenously: physiologic saline 

 solution; saline pius typhoid vaccine; normal rabbit plasma; 

 normal plasma with typhoid vaccine. Animals were observed for 

 six consecutive hours, during which total and differential 

 leukocyte counts and rectal temperatures were frequently 

 measured 



Saline and homologous plasma alone were without effect. Plasma - 

 typhoid injections produced high fever, initial heterophile 

 leukopenia and secondary heterophile leukocytosis. Saline- 

 typhoid solutions produced only initial heterophile leukocytosis. 

 Both these groups developed mononuclear leukopenia with the 

 plasma -typhoid combination producing a more pronounced drop. By 

 increasing the number of organisms in the saline suspension 

 tenfold, it was possible to produce a response similar to that 

 seen after plasma-typhoid injections, and conversely, reduction 

 of cells in plasma -typhoid suspensions brought an initial hetero- 

 phile leukocytosis. Five variables must be considered when 

 using the leukocyte count as an index for the pyrogen test: 

 amount of pyrogen; time at which the observation is made; differ- 

 ential composition of the leukocyte population; the type of 

 bacteria in the source; the media used for suspensions. 



637. Fever therapy i« asthma 



Queries and Minor Notes. J. A.M. A. I44:l4l9, I950 



"The salutary effect of acute febrile disease on allergic mani- 

 festations has been known for centuries. Chronic and intractable 

 asthma frequently becomes more completely relieved by inter- 

 current non-respiratory infection than by almost any other means." 

 The mechanism by which benefits are achieved is not clearly de- 

 fined. Typhoid vaccine, colloidal sulfur and malarial therapy 

 have been employed as has high frequency current. "More recently 

 a pure carbohydrate constituent obtained from certain bacteria 

 and known as PYROMEN has been used to produce fever." 



638. PLENSBORQ, E. W. 



General reactions following treatment of asthma in children with ' 

 bacterial vaccine (English) 



Ugeskr. f. Laeger 112:392-399, 1950 



