22^ 



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642c GOSSELIN, W. 



Effets des polysaccharides sur le sarcome de la sourls (Effects] 

 of polysaccharides upon the mouse sarcoma) 



Rev, brasll Cancer 3;27-505 1950 



While mice tolerate dosages of the polysaccharides of S. marces -l 

 cens 1000 times higher per unit of body weight than do human 

 beings^ 25 to 50^ of the animals die with 24 hours. A method 

 of reducing toxicity of the material is a prerequisite for its 

 use in extensive cancer therapy. Antihistamines do not reduce 

 toxicity, nor does vitamin B^. Rutin (1.0 ml. of 0.1^ to 50 

 gammas of the polysaccharide) brought about the survival of 11 

 out of 12 animals, and did not affect the hemorrhage-inducing 

 and necrotic qualities^ which suggests that the hemorrhagic 

 action of the polysaccharides does not depend on capillary 

 fragility o 



643. GRANT, R. 



Emotional hypothermia in rabbits 



Am. Jc Physiol. 160:285-290, 1950 



A transient hypothermia may be induced in rabbits by light 

 restraint as well as by any activity which may activate heat 

 loss mechanisms. Cold, applied or environmental, may inhibit the 

 phenomenon, as do pyrogen injections. When 5 gammas of PYROMEN, 

 prepared from Ps, aeruginosa ., were given intravenously to a re- 

 strained anlmaT~that had recently regained its normal temperature 

 after a hypothermic period, interruption of the fever began about 

 1 hour after injections as shown by ear vasodilation and polyp- 

 noea. The temperature fell to 1.25° below normal then stabil- 

 ized at this level o In the unrestrained animal an initial drop 

 in temperature was succeeded by an intense febrile state with no 

 subsequent hypbthermia. Modification of cerebral cortical con- 

 trol upon thermoregulation is postulated. Pyrogens may act on 

 the motor mechanism of thermoregulation and not on higher centers 

 of control, Anlm.als used in pyrogen testing should not be re- 

 strained, 



644, GRANT, R, and HIRSCH, J, D. 



Pyrogen fever in rabbits; Effects of adrenalectomy 



Am, J„ Physiol o 161j 528-533, 1950 



In a preliminary study, changes in rectal and ear temperature and 



