225 



- 1 9 5 - 



in the respiratory rate of the adult rabbit were recorded after 

 the intravenous injection of 0.1 ml. per kg. of PYROMEN, con- 

 taining 50 gammas per ml. of purified pyrogen. Seven days later 

 a comparable amount of PYROMEN was injected and the effect on 

 oxygen consumption observed in a part of the group. Bilateral 

 adrenalectomy was then performed in two stages, 2 to 6 weeks 

 apart and DCA implanted subcutaneously. After stabilization of 

 rectal temperature and body weight, the effect of PYROMEN was 

 again studied. When animals were maintained in a healthy state 

 through use of DCA, adrenalectomy affected the course of 

 pyrogen-induced fever but little. It is suggested that the re- 

 moval, by adrenalectomy, of inhibition exerted on shivering by 

 epinephrine may underlie a mechanism which leads to calorigenesis. 



645. GRANT, R., HIRSCH, J. D. and HIRSCH, B. B. 



Pyrogen fever in rabbits: Effects of adrenalectomy and thyroid- 

 ectomy 



Federation Proc. 9:50, I95O 



Shivering appeared to increase oxygen consumption following 

 adrenalectomy with subsequent maintenance on DCA. No other effect 

 on the normal responses to pyrogen injections could be remarked. 

 Thyroxine, after thyroidectomy, had no effect upon normal re- 

 sponses to pyrexial agents. While neither the adrenals nor 

 thyroid are essential intermediaries in fever production, the 

 mechanism by which heat is produced may be altered in the adrenal- 

 ectomized animal; increased shivering with subsequent thermal 

 response may be caused by shivering precipitated by the removal 

 of the inhibition normally exerted by epinephrine. 



646. HARKNESS, W. D., LOVING, W. L, and HODGES, F. A. 



Pyrexia in rabbits following injection of filtrates of typical 

 mold cultures 



J. Am. Pharm. A. 39:502-504, 1950. Abstract, Federation Proc, 

 9:282, 1950 



When injected intravenously, preparations from I6 out of 31 

 species of mold cultures brought elevations in the body temper- 

 ature of the rabbit. A medium containing dextrose and peptone 

 (Sabouraud) was required for production of pyrogenic characteristic 

 inorganic salts and N sources in the medium restrained its develop- 

 ment. 



647. HARKNESS, W. D. and VOS, B. J. 



Comparison of the effects of injection of pyrogenic solutions by 



