228 



- 1 9 5 - 



0.15^, reduced cleavage from 100^ (In seawater) to 0.5^. Excess 

 sperm additions reduced the degree of Inhibition. The Increase 

 in protoplasmic viscosity before mitosis was also prevented. 

 Use of the polysaccharide or dicumarol in cancer therapy is 

 discussed. 



651. HEILMEYER, L. 



Angange einer Chemotherapie neoplastischer Erkrankungen 

 (Chemotherapy of neoplastic diseases) 



Schweiz. med . Wchnschr. 79:530-5^7, 19^9 and Naturwissenschr. 

 37:58-65, 1950 



In reviewing the literature dealing with the Effects of chemical 

 cytostatics upon the cells of tumors, other active substances 

 are considered. In addition to cell nucleus toxins (colchicine, 

 trypaflavine, the urethanes, mustard gases, stilbamidine, aminop- 

 terln and metallic salts) other active materials, including the 

 polysaccharides and pyrogens, hormonal substances and radioactive 

 preparations, are effective under certain conditions. 



652. HEISTJZr, H. 



Pyrogene reaksjoner, med saerllg henblikk pa deres forebyggelse 

 (Pyrogenlc reactions with special considerations of their ore- 

 vention) '^ 



Tidsskr. norsk. laegerfor. 70:264-266, 1950 



In parenteral therapy dangers of unpleasant reactions exist when 



pyrogens are present. Prevention may rest in careful production 



of material destined for injection, in elimination of pyretic 



substances after production and the cautious approach to initial 

 therapeutic application. 



653. HEYMAN, A., PATTERSON, J. L,, JT^ . and NICHOLS, F. T., JR. 



The effects of induced fever on cerebral functions in neuro- 

 syphilis 



J. Clin. Invest. 29:1335-13^1, 1950 



Fever was induced in 27 patients thro 

 pyrogens, malaria parasites or induce 

 function changes in dementia paralytl 

 syphilis were assessed. Pyrogenlc ma 

 organisms per cc. or 0.1 cc . each inj 

 ranged between 101.0 and 104.0 degree 

 response, cerebral blood flow, oxygen 



ugh use of typhoid bacterial 

 d hyperthermia. Cerebral 

 ca or asymptomatic neuro- 

 terlal averaged 1 billion 

 ection. Rectal temperatures 

 s. At the height of pyrexia! 

 consumption and arteriovenous' 



i 



