231 



- 1 9 5 - 



in macrophages of the spleen, liver and heart and in peritubu- 

 lar capillary endothelium of the kidneys. 



The smallest dose of polysaccharide to produce a positive preci- 

 pitin reaction in serum and detectable quantities in cells in 

 24 hours was 0.03 mgo A comparison of the distributions of 

 polysaccharide, acid dyes and suspensoids is made. Possible 

 relationships between distribution, antigenicity and toxicity 

 may exist. 



659. KASS, E. H., and. FINLAND^ M„ 

 Effect of ACTH on induced fever 



New England J, Med. 243:693-695^ 1950 



Varying numbers of killed typhoid bacilli were injected intra- 

 venously in two patients with chronic rheumatoid arthritis, 

 prior to or after Administration of ACTH. The duration and 

 intensity of the febrile response was reduced by administration 

 of ACTH in advance of the pyrogen. That the antipyretic effect 

 of ACTH is not to be credited to tolerance developed toward 

 pyrogens has been confirmed in the rabbit. The mechanism by 

 which ACTH exerts the antipyrexial effect is not known. There 

 is no alteration of the fundamental pathologic process of the 

 illness under treatment. It is necessary to differentiate 

 between antipyretic and antipathologic results after the use 

 of ACTH. 



660. KIERLAND, R. R, and KULWIN, M, H. 



Clinical evaluation of a new pyrogenic agent 



A.M. A. Arch. Dermato & Syph, 62:571-572, 1950 



The pyrogenic agent, PYROMEN, was used clinically in 46 derma- 

 tologic patients suffering from a number of diseases. The usual 

 initial dose was 25 micrograms given intravenously; subsequent 

 dosages were based on the production of oral temperatures of 

 102,0 degrees F. The drug was administered on alternate days. 

 The largest amount given in a single injection was 125 micro- 

 grams; the greatest number of injections given to one patient 

 was ten. 



Results showed PYROMEN produced a sa-tisfactory "therapeutic" 

 fever. Individual duration of temperature elevation was fairly 

 "constant and . . „independent of the dose of the material injected." 

 Untoward side reactions were few and mild. The authors conclude 

 that PYROMEN "is a Safe agent for use in producing therapeutic 

 fever" since the results compared favorably with those obtained 

 by the use of typhoid vaccine and lacked certain unpleasant side 

 effects noted with the latter preparation. 



