235 



- 1 9 5 - 



668. NOOJIN, R. 0,, PACE, B, P. and PRAYTOR, H. B. 



Prolonged fever produced by three injections of typhoid vaccine 



Am. J, Syphilis 3^: 153-160, 1950 



The advantages Inherent in typhoid vaccine fever therapy are: 

 (1) easy administration, (2) controllability, (3) development 

 of natural resistance, (4) simplicity, (5) inexpensiveness, 

 (6) no after-treatment as with malarial therapy and (7) mini- 

 mum side effect. Some of the disadvantages are: (1) hospi- 

 talisation is required, (2) timing of fever is needed, and 

 (3) some hypersensitivity may be exhibited. If the rise in 

 fever is considered as proportional to the benefits derived, 

 20 million organisms should be injected intravenously, follovx^ed 

 by subsequent injections at two-hour intervals for the first 

 two doses, then three times per day for the duration of the 

 course of treatment. 



669. PIORKOWSKI, G. 



VJirkungssteigerung fiebererzeugender Mitt el bei gleichzeitiger 

 intravenb'ser and intracutaner Anwendung (Increased efficacy of 

 fever-producing drugs by using combined intravenous and intra- 

 cutaneous application) 



Med. Klin. 45:630-631, 1950 



670. RALL, D. P., and WELLS, J. A. 



Inhibition of thermal panting by bacterial pyrogen 



J. Pharmacol, cc Sxper, Therap. 9-3:27, 1950 



Failure of the dog to pant in response to pyrogenic fever is 

 interpreted as being, in part, due to inhibition of the thermal 

 canting mechanism. Chronic cord transected dogs responded to 

 environmental temperature elevation with fever (103.5-105^'?. ) 

 and panting. The latter was inhibited by introduction into a 

 running venoclysis system of purified pyrogens from Pr. vulgaris 

 or Ps. aeruginosa (PYROMEN). The degree of inhibition closely 

 followed increases in dosage, and respiratory rate decreased 

 sharply after injection of 0.04 to 1.2 xng, pyrogen; average re- 

 duction in 15 to 30 minutes ranged between 15 and 53 per cent. 



671. RANDOLPPI, T. G. and TOLLINS, J. P. 



Pyromen in the treatment of perennial allergic symptoms 

 Ann. Allergy 8:626-640, I95O 



