236 



- 1 9 5 - 



A group of 150 patients has been treated with PYROMEN, Intra- 

 venously, orally or by a combination of the two routes, over 

 periods ranging from 10 days to 8 months. Subpyrexial doses of 

 0.5 to 10.0 gammas have been employed. The frequency of ad- 

 ministration has been dependent on the allergic manifestation 

 treated and the degree of control obtained. PYROMEN therapy 

 has been found to be most efficacious in treatment of those 

 patients for v.'hom partial or complete specific diagnosis had 

 been made; a combination of PYROMEN therapy with Inhalant 

 desensitizatlon has resulted in excellent management of peren- 

 nial allergic symptoms. The authors believe that beneficial 

 effects obtained during this study may be the result of stimu- 

 lation of the pituitary-adrenal system. Side effects with this 

 therapeutic regimen have been infrequent and mild in nature. 



672. REINHARD, E. H,, GOOD, J. T. and MARTIN, E. 



Chemotherapy of malignant neoplastic diseases 



J. A.M. A, 142:383-390, 1950 



In a lengthy discussion of chemotherapeutic agents used in the 

 treatment of neoplasms, the authors discuss the potency of S. 

 marcescens polysaccharide, the reticuloendothelial cytotoxic 

 sera and other biologic antineoplastic agents. Toxicity is the 

 limiting factor in application of the polysaccharide of S. 

 marcescens . 



673. RODBARD, S., SACI, H. and MALIN, A. 



Body fluid redistribution in induced hypothermia and hyperthermia 

 Federation Proc. 9:107, I950 



Actual fluid volume and fluid shifts in hyperthermia and hypo- 

 thermia were determined in both rabbits and chicks. The data 

 suggest that there is a marked shift from plasma and interstitial 

 spaces to the intracellular phase during hypothermia, but hema- 

 tocrit and specific gravity do not show equivalent Increases. It 

 is suggested that both blood cellular elements and plasma proteins 

 may be stored. This phenomenon is reversed during hyperthermia 

 as water leaves the cells of tissue and releases plasma protein 

 and red cells into the circulating blood. 



