237 



- 1 9 5 - 



674. RODNEY, G., and DEVLIN, H. B. 



Chemical composition of some bacterial pyrogens 



Federation Proc . 9:220, 1950 



Pyrogens in a purified form were isolated from strains of B. 

 prodiglosus , B. subtllis , Ps . aeruginosa and E. typhi grown on 

 symthetlc medTa, After digestion, nucleic acTd and pyrogens 

 were removed, and the latter was fractionated by means of or- 

 ganic solvents. Carbohydrates present in hydro lysates were 

 quantitatively separated by filter paper partition chroma- 

 tography. Analyses for nitrogenous materials and phosphorus were 

 made. Pyrogen from different sources differed in composition 

 both as to quality and quantity; activity also differed. The 

 most active pyrogen was obtained from B. prodiglosus which ini- 

 tiated reactions in rabbits in concentrations of 0,01-0,005 micro- 

 grams per kg. body weight, 



675. SCHMENGLER, R, D, 



Effect of fever shock therapy in acute rheumatic and allergic 

 diseases. Its significance for acute rheumatism (Translated 

 Title) 



Klin. Wchnschr, (Heidelberg) 27:1027, 1950 



A vaccine produced from the colon bacillus (pyrifer) was injected 

 in varying amounts into patients who presented the following 

 pathologic entities: (l) acute rheumatic polyarthritis; (2) 

 acute rheumatic fever without joint Involvement; (3) poly-symp- 

 tomatic rheumatic conditions, often with cutaneous lesions; (4) 

 acute allergic disorders with known antigens. 



Following therapy prompt defervescence occurred and the local 

 symptoms disappeared. A sympathetic reaction is postulated; 

 a cellular anaphylaxis may set in motion a sympathetic response 

 ending in pathologic processes. This latter response is reversed 

 by pyrifer. 



676. SCHOLTZ, H. G. 



Physlkallsche Hyperthermle Oder Pyrlferfieber? (Physical hyper- 

 thermia or fever Induced by pyrifer?) 



Arch, phys, Therap. 2:53-56, I950 



677. SMITH, J. McC. and MIRICK, G. S. 



The inhibitory effect of bacterial suspensions on pneumonia 



