239 



-19 5 0- 



hourso Dispersion of granules of mast cells began between 2 

 and 15 minutes after administration of PYROMEN with most rapid 

 alterations evident in areas near small blood vessels. 



680. STUTTGEN, Go 



Pyrifer als antigen im rahmen der baktercellen autoallergic 

 (Pyrifer as an antigen in the picture of autoallergy of the 

 bacterial cello) 



Zeitschro Haut u. Geschleetskr, 9:17-20, 1950 



681. SWINEPORD5 0,5 JRo 



Observations on the use of bacterial antigens in the treatment 

 of asthma. A brief critical review 



Am. Pract. I:6l2~6l8, 1950 



The author presents summarized data from twenty-eight authors 

 who have reported on the treatment of asthma with bacterial 

 antigens. Characteristics, clinical and laboratory, of atopic 

 and tuberculin allergies and of the Arthus reaction are enumer- 

 ated. The treatment by such means is empirical but of definite 

 value. 



682. TAKOS, Mo J, and MOE, G. K. 



Prevention of pyrogen-indueed renal hyperemia in the dog by 

 dihydroergocornine 



Proco Soc, Expero Biolo & Med. 75:51-52, 1950 



After control periods in which glomerular filtration rate and the 

 effective renal plasma flow were determined, dihydroergocornine 

 (DHO) was administered to female dogs (0.01 rag, per kg. intra- 

 venously and a like amount subcutaneously) and followed by a 

 pyrogen derived from Shigella organism. Rectal temperatures 

 were recorded. Comparisons were made with controls receiving 

 pyrogens alone, and all experiments were repeated » 



In animals treated with pyrogen alone, the renal plasma flow 

 Increased 27 to 79 per cent while the glomerular filtration rate 

 remained within normal limits. DHO is an alkaloid known to 

 interfere with certain central autonomic mechanisms. Premedi- 

 cation with this drug brought a great reduction in renal hyper- 

 emic response, with a range of -4 to plus 25^» It did not affect 

 the glomerular filtration rate or inhibit fever. The antagonism 

 between pyrogen and DHO is presumed to indicate a blocking action 

 on the central nervous system by the alkaloid. 



683. TAL, C, and GOEBEL, W. P. 



