- 1 9 5 - 



On the nature of the toxic component of the aomatlc antigen of 

 Shigella para^yaenterlae type Z (Pl#xner) 



J. Bxper. Med. 92:25-3*, 1950 



The toxic component of the sonatlc antigen of dysentery 

 bacilli appears to he neither the lipid, protein or carbohy- 

 drate of the complete antigen. Fractions disassociated from the 

 complete antigen yielded a protein component nearly as toxic 

 as the original antigen; carbohydrates were still bound to the 

 protein complex. A milder procedure yielded a product almost . 

 protein free; further treatment eliminated 505^ of the total I 

 lipids but did not change serologic, antigenic or toxic proper- 

 ties. The U.V. absorption was approximately 2600<^ for one 

 component, primarily polysaccharide In nature. Further hydrolysis 

 yielded a polysaccharide, serologically active but non-toxic, 

 and an Insoluble precipitate, not Identifiable as protein or 

 lipid . 



68^. WAGNER, R. R., and BEMMETT, I. L. 



The production of fever by Influenzal viruses 



J. Exper. Med. 91:135-1^5, 1950 



Toxic bacterial filtrates which have an affinity for and de- 

 structive effect upon the cell receptors for influenzal 

 viruses diminished the febrile response to PR8 and Lee strains 

 of influenza virus and that of Newcastle disease. Both Cholera 

 vibrio and Clostridium welchii filtrates had antlpyrexlal in- 

 fluence, but near lethal amounts were necessary to demonstrate 

 a protective effect. However, the ability of animals to re- 

 spond to the pyrogenlc effect of typhoid vaccine was unimpaired 

 by injection of receptor destroyers. "These findings give support 

 to the hypothesis that union of virus and host receptor substance 

 plays a part in the production of fever by these viruses." 

 Chemical substances (le; sodium perlodate) may be neutralized 

 by normal serum and allantoic fluid, since the cell receptor 

 activity was not blocked by their use; glucose is also believed 

 to neutralize the action of sodium perlodate. 



685. WALKER, L., OLSON, W. H. and NECHELES, H. 



Depression of gastric secretion with pyrogens and antipyretics 

 without fever 



Am. J. Physiol. 163:758, 1950 (Abstract) 



Increases In the temperature of the body may cause a partial 

 or complete inhibition of hydrochloric acid secretion by the 



