241 



-19 5 0- 



stomach. Injection of pyrogens can produce temperature eleva- 

 tions with inhibition of gastric secretion and, may be capable 

 of depressing secretory ability when subpyrexial quantities are 

 administered. After histamine stimulation, pyrogens in sub- 

 pyretic dosages were injected into dogs with total gastric 

 pouches „ The inhibitory effect was not constant. When larger 

 pyrogen increments were utilized, consistent inhibition of se- 

 cretion was obtained even after the temperature elevation was 

 abolished by antipyretics o Sixty per cent reduction in total 

 voluem of gastric juice and 72 per cent reduction in total 

 mEq, of free HCl accompanied this Alteration, produced by in- 

 jection of 50 gammas of PYROMEN, and 10 grains of aspirin 

 given orally, A latent period of 30 to 60 minutes preceded 

 these findings. 



686. WAUER, D, 



Innere Abteilung des Stadtischen Behring-krankenhauses Berlin- 

 Zehlendorf a Zur Pyrifertherapie akuter und chronischer Leber- 

 parenchyraschaden (Treatment of acute and chronic involvements 

 of the liver parenchyma with pyrifer) 



Deutsche Gesundheitsw, 5:489-^92, 1950 



Nonspecific desensitization with pyrifer as anti-allergic agent 

 was beneficial in both acute and chronic hepatic parenchymatous 

 conditions. Allergy may be etiological in many hepatopathies, 

 and pyrifer activity is considered one producing a change in cap- 

 illary permeability. 



687. WINDLE, W. P. 



Changes in the hypophysis and suprarenal glands induced by a 

 bacterial pyrogen 



Anat. Recc 106:94-95, 1950 



Histologic studies were made of the organs of 32 virgin female 

 rabbits previously treated with a new purified bacterial pyrogen, 

 P.V. PYROMEN, and these were compared witt or^ns from six 

 controls. The average dose of PYROMEN was either 1 or 5 gammas 

 per kg. body weight. Six animals received 0.01 to 0.1 gammas 

 per kg, J six others received very high dosages (500 to 20,000 

 gammas per kg,). The LDcq is 80,000 gammas per kg. Tissues 

 were prepared with perfusion formalin fixation and hematoxylln- 

 eosin staining procedures, 



PYROMEN appeared to act as a mild stress stimulus, but no animal 

 exhibited lesions resembling those seen in exhaustion stages of 

 the general adaptation syndrome. Changes in endocrine organs 



