I 



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691. WINDLE, W. P., CHAMBERS, W, W., RICKER, W. A., GINGER, L. G. 

 and KOENIG, H» 



Reactions of tissues to administration of pyrogenlc preparation 

 from a Fseudomonas species 



Am. J. Med. Scl, 219:422-426, 1950 I 



Sensitivity to PYROMEN was shown In test animals In the follow- 

 ing descending order: dog, rabbit, cat, monkey, guinea pig and 

 rat. Administration of massive doses Induced histological 

 changes In lymphoid and myeloid organs similar to those ob- 

 served with other pyrogenlc substances or pyrogen-free saline so- 

 lution. There was Increased macrophage and lymphocyte pro- 

 duction In all species studied; where treatment was prolonged, 

 myelocyte and granulocyte production In the spleen of the rabbit 

 was noted. 



692. WINDLE, W. P. and WILCOX, H. H. 



Extramedullary hemopoiesis In rabbit and cat Induced by bacterial 

 pyrogens 



Am. J. Physiol. 163:762, 1950 



Histological changes In the spleen after PYROMEN are related to 

 time of treatment and 'en some degree to the size of the dose. 

 Most marked changes were observed In the red pulp, where proli- 

 feration of reticular cells and reduction of blood flow through 

 sinuses were noted during the first 20 days of treatment; where 

 treatment had been continued a month or more, phagocytosis of 

 static blood by macrophages was noted. Groups of hemopoietic 

 cells appeared In pulp cords. 'Islands' of hemopoietic tissue, 

 similar to those found in embryonic states, were seen in sinuses j 

 of the spleen. When the dosage was massive or therapy prolonged 

 the hematopoietic picture resembled, for the spleen, that of bone 

 marrow. The greatest Increases In spleen weight occurred in the 

 cat, but hepatic hemopoiesis was noted in the rabbit after massive 

 or prolonged therapy. Hepatic activity was not noted In controls 

 nor with lower dosage levels of PYROMEN. 



693. WINDLE, W. P., WILCOX, RHINES, R., and CLEMENTE, C. 



Changes in endocrine organs Induced by bacterial pyrogens 



Pederatloh Proc. 9:137, I950 



The organs of rabbits were examined histologically for signs of 

 stress -linked changes after administration of Ps. PYROMEN 



