2^5 



-19 5 



(100, 000-200 <, 000 gammas total dosage) :, Treatment extended from 



19 to 303 days. Comparisons were made with the appearance of 



organs after 500-20i,000 gammas per kg,, body weight of P„Vo PYROMEN 

 had been administered for 3 to 6 weeks. 



Neither group had organs typical of the exhaustion stage associ- 

 ated with the general adaptation syndrome <, Ps, PYROMEN-treated 

 rabbits exhibited hyperplasia ^ hyperactivity of lymphatic and 

 reticuloendothelial tisBues^ while PoVo PYROMEN induced but 

 slight changes In these tissues o Both preparations produced 

 blood component alterations resembling those seen after stress 

 or following the administration of ACTHo Changes suggestive of 

 involution after marked growth stimulation of the adrenal cor- 

 tex were noted. 



Rabbits and rats given P»Vo PYROMEN thrice weekly (to 122 days) 

 in dosages of 1 or 5 gammas per kg, body weight exhibited in- 

 creased cytoplasmic activity 3„n endocrlnes. Vacuolization of 

 anterior lobe basophils and cells of the pars Intermedia of the 

 hypophysis appeared within 12 hours <> Similar changes appeared 

 in adrenal cortex after prolonged administration; at higher 

 dosage levels involutional changes were seeno 



WIRTH^ P„ 



Uber Pyrlferbehandlung bei schwerer Dlphtherie (Fever therapy 

 (pyrifer) in severe diphtheria) 



Deutsche med, Rscho 42 204-206, I95O 



Seventy-one of 133 patient© treated with antitoxin and peni- 

 cillin were given a bacterial pyrexial agent ^ with the result 

 that recovery was more rapid and less difficult „ Mortality 

 appeared to be reduced by adjuvant therapy. Neurological com- 

 plications were unchanged , 



