- 1 9 5 1 - 



695. ALGIRE, G. H. and LEGALLAIS, P. Y. 



Vascular reactions in normal and malignant tissues in vivo. IV. 

 The effect of peripheral hypotension on transplanted tumors 



J. Nat. Cancer Inst. 12:399-^21, 1951 



The transparent chamber technique was used in making microscopic 

 observations of changes in the blood supply of transplanted 

 tumors when peripheral blood pressure was reduced. Direct corre- 

 lation between hypotension and reduction of circilalation in capil- 

 laries of tumors and surrounding tissues in the host was secured. 

 Reduction of tumor circulation was related to the duration and 

 degree of peripheral hypotension. Necrotic changes in tumor tis- 

 sue follow in prolonged reductions. A- polysaccharide from 

 Serratla marcescens furnishes a mechanism which may be related to 

 this phenomenon: progressively increasing sluggishness of flow 

 in the arteries; stasis of blood; occlusion of capillaries in 

 striated muscle; necrosis in sarcoma tissue. In the latter in- 

 stance, hemorrhage follows ischemia within a few hours and tumor 

 damage may be apparent in 24 hrs. thereafter. Work is now in pro-< 

 gress to determine whether hypotensive effects are responsible 

 for the therapeutic benefits achieved. 



696. ARCHER, B. J. 



Remission in rheumatoid arthritis following fever therapy with 

 liver damage 



New York J, Med. 51:2657-2658, I951 



Cephalin flocculatlon tests became positive soon after initiation 

 of therapy with injections of typhoid bacteria in a patient re- 

 sistant to the effects of gold salts and salicylates. The ele- 

 vated sedimentation rate returned to normal and remission of arth- 

 ritlc symptoms followed. The cephalin index returned to normal at 

 the time of relapse, two weeks later. 



697. BECK, L. V. 



Reducing substances as Indicators of protection afforded by cort- 

 isone against tumor -damaging effects of Serratla marcescens poly- 

 saccharide 



Cancer Res. 11:4, I95I 



Marked decrease in the content of reducing substances - ascorbic 

 acid and glutathione - accompanied hemorrhagic necrosis Induced 

 in mouse sarcoma #37 by arsenlte, a-peltatln and P25, the poly- 

 saccharide from S. marcescens . When 5 micrograms of cortisone 

 per Gm. mouse weTght were Injected before P25, the minimal dose 

 of the polysaccharide required for production of tumor necrosis 



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