247. 



- 1 9 5 1 - 



was doubled. It was shown that the minimum dose of P25 required 

 to decrease ascorbic acid and glutathione content of tumors is 

 twice that required when preceded by injections of cortisone. 



698. BRIL' M T, Knokhitkin 



Metodke pirogennoi terappii sifilisa (Method of Pyrogenous 

 Syphilis Therapy)" 



Vestnik vener. dermat. 1951(3) 28-31 



CHARONNAT, R. and LECHAT, P. 



Investigaciones sobre el ensayo de los pirogenos en los solu- 

 ciones inyectables (Investigations on the test for pyrogens in 

 injectable solutions) 



Laboratorio, 10:545-556, I950 



I 



700. CHARONNAT, R, and LECHAT, P. 



Researches sur la nature des pyrogenes des solutes injectables. 

 I. Substances definies d'orlgine biologique ayanat une action 

 pyrogene (investigations into the nature of pyrogens in injec- 

 table solutions) \ 



I 

 Ann. pharm. franc. 9:17-22, I95I |J 



The pyrogen of Robinson and Plusser appeared to be a polysaccharide 

 approximating 62,000 molecular weight, containing 0,29-2.38^ P 

 but without azotes. Menkin's "pyrexine" has 11^ N, but 1^ P, 

 gives no Molisch reaction and is considered to be a glucopeptide. 



In a series of experiments, pyrexial substances, both bacterial 

 and chemical, were injected intravenously into the rabbit. Prom 

 an opotherapeutic product, a substance was extracted which was, 

 when purified, insoluble in water but soluble in monosodium car- 

 bon solution, 0,1 mg,/kg,, in the rabbit, elevated temperature 

 from 1 to 4 degrees. Nucleic acids, thymonuclelc acid, and a 

 7% nucleotide solution were also investigated. Adenylic acid was 

 not pyrogenic . Adenosine (three types) had specific hyperthermic 

 action, but it was believed that an impurity was responsible. 



701. CHARONNAT, R. and LECHAT, P. 



Researches sur la nature des pyrogenes des solutes injectables. 

 IIo Essais de definition quantitative des substances pyrogenes. 

 III. Indice pyrogeniques (II. Tests of quantitative definition 

 of pyrogenic substances. III. Pyrogenic indices) 



Ann. pharm. franc. 9:22-30, I95I 



