-19 5 1- 



II. After extended studies It could not be confirmed that the 

 log of hyperthermia provoked by the pyrogen of B. pyocyanae us 

 has the relationship of a linear function to the logarithm of 



the dose, 



i 

 III. An empiric formula is presented which may be employed to 

 correlate the hyperthermic curve and amounts of pyrogens injected. 

 The law involved is one far more complex than that of a straight 

 line function. The pyrogen unit is not an index. 



702. CLEMENTE, C. D. i. 



Production of periods of leukocytosis and tolerance by conse- 

 cutive oral administrations of different bacterial pyrogens 



Federation Proc. 10:27, 1951 



Tolerance to oral administration of several bacterial pyrogens 

 J^^o" f Paeudomonas species, Pr. vulgaris and B. subtilis) fol- 

 lowed leuKocytosis. Normal wHTte cell levels reappeared . To 

 differentiate between a generalized effect of PYROMEN and possible 

 existence of species differences, 1 gamma Ps. PYROMEN was fed in 

 drinking water daily. In 2 to 5 days the total white count had 

 ascended from an average of 16,000 leukocytes per cu. mm. to 

 levels between 29,000 and 35,000. Normal levels reappeared in 

 '4 2? ^^^^^' ^^^^ ^^® pyrogen employed was one obtained from 

 either Pr. vulgaris or B. subtilis , a secondary leukocytosis was 

 evoked and a second period of tolerance followed. In some animals 

 the period of white cell elevation extended to 20 days. The most 

 prolonged results were achieved with Pr. vulgaris pyrogen. 



'^^^' and^raOLE^V^'p ^"^'^^^^ ^' ^" GREENE, L. C, MITCHELL, S. Q. 



Regeneration of the transected spinal cord of adult cats 

 Anat. Rec. 109; 280, 1951 



Certain bacterial pyrogens assist in inhibiting collagenous scar- 

 ring after complete spinal cord resection. Loose reticular and 

 macrophage matrices are substituted for scar tissue. The pene- 

 tration of intraspinal nerve fibers on regeneration is thereby 

 rendered possible. Regenerative activity was demonstrated histo- 

 logically when 20 gamma of PYROMEN per Kg. body weight were ad- 

 Tr^^J^^®*^ initially to spinal cats and the amounts Increased 

 (to 200 gamma per Kg. body weight) for successive periods of ap- 

 proximately two weeks each. Treatment alternated with rest periods. 

 When the treatment was discontinued prematurely, growth of the 

 dense collagenous tissue was resumed. 



