249 



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CLEMENTE, CD., CHAMBERS, W. W. and WINDLE^ W. F. 



Blending of regenerating peripheral fibers with cerebral cortex 

 through glial barrier Inhibition 



Am. J= Physiol, 167:77^^ 1951 



The published observations of Windle and Chambers (1950) and 

 Cleraente and co-workers (1951) on the anatomical regeneration of 

 severed spinal cords of adult cats have been augmented through a 

 report of the results obtained when peripheral nerves were im- 

 planted into the cerebrum. The proximal stump of the temporal 

 branch of the right facial nerve was implanted into the cerebral 

 cortex of subject and control. One animal received a bacterial 

 polysaccharide intravenously (PYROMEN) for a period of 30 days. 

 Sections of cerebral tissue stained with silver were examined. 

 No sharp demarcation between peripheral nerve and brain paren- 

 chyma could be seen in tissue following PYROMEN therapy. The 

 regenerating fibers grew radially and blended with the substance 

 of the cerebrum. In untreated tissue., distinct glial barriers 

 were seen and no blending was observed o 



CLOUGH, P. W, 



Pyrogens . 



Editorial, Ann. Int , Med. 34:8l6-8l9r 1951 



The literature on the therapeutic applications of pyrogenlc sub- 

 stances is partially reviewed. Present use of pyrogens is, ac- 

 cording to the author, confined to attempts to stimulate certain 

 defense mechanisms. "This is most evident in such diseases as 

 uveitis and other ocular infections. ,, it might be used more fre- 

 quently than it is in certain other types of Infection for which 

 no specific therapy is available and which are resistant to less 

 drastic procedures,,.." Application of pyrogens in the therapy 

 of (a) inoperable neoplasm.s (b) malignant hypertension appears 

 to be promising but is limited by severity of the reaction. In 

 summarizing, the editor states that "this form of treatment is., 

 still in the early experimental stage" . 



The characteristics of bacterial pyrogens, clinical manifesta- 

 tions following their administration^and the increases in toler- 

 ance seen after continued pyrogen therapy are briefly discussed. 

 Abolition of pyrogenlc reactions has been secured through use of 

 antipyretics, ACTH and cortisone, or reticuloendothelial block- 

 ading agents. 



FARIA, R. 



Post-transf usional reactions. A clinical and statistical study 



