255 



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polymorphonuclear cells to levels above those secured with other 

 hyperthermic agents. It is possible that both immunization and 

 toxic effects (not mediated through the anterior pituitary) occur 

 with Pv PYROMEN therapy, Pv PYROMEN does not increase urinary 

 corticosteroid excretion, but this may merely imply that the 

 renal threshold is high, " , , .with normal oituitary glands, fever 

 and pyrogenic substances may cause the release of small amounts 

 of ACTH..." the authors believe, 



716. LEQUKE, V. So 



The augmentation of the thermogenic effects of pyrogens by homo- 

 logous plasma in rabbits 



J. Infect, Dis., 83; 194-206, 1951 



Mechanisms involved in the augmentation of pyrogenic response by 

 use of homologous plasma were demonstrated through studies of 

 the minimal and moderate febrile reactions in the rabbit after in- 

 jection of saline or plasma suspensions of pyrogens from E, tv- 

 phosa , P. aeruginosa , Aerobacter cloacae and PR-8 Str . influenzae . 



Thermogenic response and duration of reaction were heightened 

 when plasma was the suspending fluid. The latent period before 

 initial temperature elevation was shortened.. An exception v,'as 

 noted when influenza virus A was injected; the febrile reaction 

 proceeded to peak levels regardless of the material used for sus- 

 pension, although time of onset and duration were extended through 

 the use of plasma. The pyrogens from E, typhosa were completely 

 removed from the blood stream within 15 minutes when a saline med- 

 ium was used for the suspending fluid; with plasma, fever was pro- 

 longed for two hours. Heparin decreased the pyrogenic activity 

 of E, typhosa and restored a latent period; heparin itself was 

 pyrogenic. With plasma in combination with heparin a febrile re- 

 sponse could be obtained. 



When plasm.a pyrogens were pretreated through suspension in this 

 medium, clearance time was prolonged. The activity of pyrogens 

 appears to be a selective precipitation of fibrin and aggluti- 

 nation of the bacterial coat. It is believed that pyrogens do 

 not act directly on the temperature regulation centers,, when com- 

 bined with plasma but alter the surfaces of bacteria or react with 

 certain blood constituents. It was noted that influenza virus A 

 immune serum abolishes leukocytosis and pyrogenic activity. 



717. MARTIN, S, P, 



Effect of a group of bacteria and their carbohydrates on human 

 leukocytes 



Am, J, Med, 11:246, 1951 (Abstract) 



