258 



- 1 9 5 1 - 



721. MOST, S. 



Effect of Shear's Polysaccharide on plasma clotting 



Nature, 168:3^2, 1951 



It has been previously suggested (Heilbrunn, Wilson and others) 

 that the polysaccharide extracted from the bacterium, S. marces - 

 cens may have heparin-like structure and activity » The action 

 was presumed to involve prevention of mitotic gelation or clot- 

 ting before division o Like heparin, the substance gives a meta- 

 chromatic reaction with toluidine blue, 



A solution of polysaccharide P25, containing 36 mg, per cc,,was 

 diluted with distilled water and added to freshly oxalated human 

 plasma containing 1 cc , of 0,1 M sodium oxalate to 9 cc . of 

 blood. The clotting time at 37°C, of total volumes of 0.1 cc. 

 plasma and equal amounts of polysaccharide and M calcium chlor- 

 ide (0.025) was computed from the time of addition of the last- 

 named chemical until complete clotting had taken place. Shear's 

 polysaccharide inhibited the clotting of recalcified plasma in 

 a manner resembling that of heparin, but commercial heparin had 

 an activity : 138 to 320 times more effective for the purpose 

 stated. 



722. PAGE, I. H. 



Treatment of essential and malignant hypertension 



J. A, M. Aos 147:1311-1318, I95I 



In a review of the present status of therapy and of the possible 

 additions to the therapeutic armentarium in essential and malig- 

 nant hypertension the use of pyrogens is held to be "the treat- 

 ment of choice" in the latter condition. The author considers it 

 to be a "harsh" treatment as applied in malignant hypertension., 

 but a life-saving procedure o 



An Infusion of PYROMEN is employed in amounts sufficient to raise 

 the body temperature to 101.0 or 102,0° P, Saline solution is 

 preferred as a diluent, and 200 cc, are infused dally^ f or six 

 days a week^over a period of three to four months. Since toler- 

 ance may develop, dosages may increase to very high levels and a 

 rest period of 3 to 5 days is required. In the treatment of some 

 patients it is possible to fix a maintenance level early in the 

 treatment period. Reactions to PYROMEN may be diminished through 

 preliminary Intravenous injections of amobarbital (0,2 Gm.) or 

 tolserol (Oo5 Gm.) before Infusion. Tolserol should be well- 

 diluted to reduce dangers of venous thrombosis resulting from its 

 use. 



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