260 



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725. SCOTT, D., JR. and CLEMENTS, C. D. 



Conduction of nerve impulses In regenerated fibers of the spinal 

 cord of the cat 



Am. J, Physiol, 16? s 825, 1951 (Abstract) 



The growth of severed nerve fibers and a return of their capa- 

 city to transmit nerve impulses were observed in the cat after re- 

 section of the spinal cord and treatment with a bacterial poly- 

 saccharide, PYROMEN. Responses to stimuli in rapidly conducting 

 descending fibers to the site of the lesion and below the point 

 of severance were recorded. In the animal receiving PYROMEN ther- 

 apy, impulses conducted to the site of the lesion at 25 to 40 

 meters per second were registered at a distance some 20 mm. 

 below the lesion. Neural activity below the site of resection was 

 undiminished in velocity. No activity could be demonstrated be- 

 loyr the site of the lesion in the control group. Approximately 

 15J^ of the total number of nerve fibers normally present appeared 

 to be capable of conducting impulses after PYROMEN therapy, 



726. SHTAKEL 'BERG, N. A. 



Raziotle likhoradochnol reaktsil u zhivotnykh prl razlichnoi 

 lokallzatsii vvedeniia pirogennykh veshchestv. (Development 

 of fever reaction in animals in relation to injection sites 

 of pyrogenous substances) 



Pizlol. Zh. SSSR (Moskva) 37:195-205, 1951 



727. SOYLEMEZOGLU, B,, and WELLS, J. A. 



Studies on the mechanism of the leukocyte response to bacterial 

 pyrogen 



J, Pharmacol, & Exper. Therap. 101:33-3^, 1951 



The relationships between pituitary-adrenal discharge, appear- 

 ance of the alarm reaction and the activity of bacterial pyro- 

 gens, ACTH and cortisone were examined. Intravenous and intra- 

 muscular Injections of ACTH (10 mg.) or PYROMEN (500 micrograms) 

 in the dog produced widely differing results. While changes after 

 Intravenous administration of pyrogen were essentially the same 

 as those produced by ACTH given by the same route, ititramuscularly 

 ACTH induced leukocytosis and PYROMEN did not. The responses to 

 ACTH were modified by adrenalectomy. It is concluded that pyro- 

 gen-induced changes take place throu^ some mechanism differing 

 wholly or in part from that of pituitary-adrenal discharge. 



