26l 



- 1 9 5 1 - 



728. SOYLEMEZOGLU, B. and WELLS, J, A. 



Compari50n of leukoctye response to ACTH and bacterial pyrogen 

 Proc. Soc. Exper. Biol, and Med. 77:43-^7, 1951 



Removal of the adrenal gland substantially reduced the eosino- 

 philic response In the dog to ACTH but did not affect the re- 

 sponse to pyrogen. 



Normal animals received either 500 micrograms of Ps. PYROMEN 

 or Pv PYROMEN Intravenously or 10 mg. ACTH, Bilaterally adren- 

 alectomized animals received pyrogen-free saline to establish a 

 non-febrile condition, then one or the other of the preparations 

 by vein. Blood samples were examined in 5 minutes, after 15 

 minutes, 30 minutes and at hourly intervals thereafter for 6 hours. 

 Differences between leukocyte responses were observed. In the 

 normal animal the eosinopenia produced by pyrogens and ACTH 

 was similar. When adrenals were removed eosinopenia was reduced 

 in animals given ACTH, but not in pyrogen-treated dogs. Adrenal- 

 ectomy reduced total leukocytosis following PYROMEN; however, 

 other factors than pituitary adrenal discharge enter into leuko- 

 cyte changes after pyrogen administration. 



729. STARKA, J. 

 Pyrogeny (Pyrogens) 



Vojenske Zdravotnlcke Listy 20:26-28, I95I 



730. STETSON, C. A., JR. 



Studies on the mechanism of the Shwartzman phenomenon. Certain 

 factors Involved in the production of the local hemorrhagic 

 necrosis 



J. Exper. Med. 93:489-504, I951 



Many hematologic changes follow intravenous injectiora of materials 

 found capable of eliciting the Shwartzman phenomenon in the rabbit. 

 These changes include the appearance of thrombocytopenia to a 

 marked degree, a rapid accumulation of platelets and leukocytes 

 in capillaries of the lung, preliminary occlusion of the skin 

 capillaries through thrombi of platelets and neutrophils, and 

 complete interrttfltlon of the blood supply, necrosis and hemor- 

 rhage. When purified rabbit liver glycogen or agar were adminis- 

 tered Intravenously, leukopenia developed more rapidly and dis- 

 appeared more quickly than is the case after bacterial toxins are 

 injected. Glycogen produced agglutination or clumping of platelets 

 and leukocytes. Thrombi bear a resemblance to those noted before 

 severe hemorrhage in mouse sarcoma I80 after injection of either 

 glycogen or meningococcal toxin. 



