263 



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733. TENNENT, D. M. and OTT, W, H. 



Tolerance in rabbits to bacterial pyrogens 



Federation Proc , 10:396, 1951 



Studies have been made of the factors which influence the develop- 

 ment of tolerance in rabbits injected with bacterial pyrogens. 

 Special emphasis was placed upon the size of the dose and time 

 required for recovery of the normal febrile response. Tolerance 

 and recovery time were found to be functions of the amount of 

 pyrogen injected. With levels of dosage sufficient to produce 

 0.6° C. increase in body temperature, a rest period extending 

 beyond one week was necessary to restore the normal febrile 

 response in some animals. 



734. THOMAS, Lc and GOOD, R. A. 



Bilateral cortical necrosis of kidneys in cortisone-treated 

 rabbits following injection of jDacterial toxins 



Proc. Soc. Exper. Biol. & Med. 76:6o4, 195I 



Five groups of rabbits were studied after each group had re- 

 ceived one of the following: (a) 25 mg. cortisone intramus- 

 cularly daily for four days with 2 cc. of meningococcal toxin 

 intravenously (1:10 dilution) the third day, (bj meningococcal 

 toxin alone by vein, (c) 25 rag. cortisone daily for four days, 

 (d) 25 mg. cortisone per day and 0.4 mg<^ S. marcescens toxin 

 intravenously on the third day, (5) P-25 l"oxin alone. Smaller 

 doses of cortisone were administered also, and the effects of 

 shortened periods of treatment were noted e 



Bilateral renal cortical necrosis was evident in a majority of 

 the animals treated with cortisone and bacterial toxin in com- 

 bination. No changes were evident in control animals. Seven of 

 eight animals treated with 10 mg. cortisone and 0.2 rag. P-25 

 toxin developed necrotic areas in the kidneys. 



735. WELLS, J. A„ and SOYLEMEZOGLU, B. 



fSuppression of leukocyte response to bacterial pyrogen by nitrogen 

 'mustard 



J. Pharmacol. & Exper. Therap. 103:3^i 3^951 



Since the preponderance of unsegmented granulocytes in the 

 leukocyte picture following the injection of bacterial pyrogens 

 suggests bone marrow stimulation, methyl bis (b-chloroethyl) -amine 

 was administered for its anti-hematopoietic effect, the total and 



