-19 5 1- 



I 



differential leukocyte counts performed at hourly intervals 

 thereafter, and comparisons made with normal levels. In the rabbit 

 initial leukopenia was not succeeded by rises in total leuko- 

 cytes. "It is assumed that the biphasic leukocyte response to 

 pyrogen (PYROMEN) is due to irreversible removal of cells from 

 the circulation, and that the subsequent leukopenia is nor- 

 mally obscured by ^ release of newly formed cells from the bone 

 marrow* ,, 



736. WINDLE, W, P., and CHANBERS,, W. W. 



Regeneration in the spinal cord of the cat and dog 



A.M.A« Arch. Neurol. & Psychiato, 65:261, 1951 (Abstract) 



In experiments planned to determine the possible site of action 

 of a purified bacterial pyrogen (PYROMEN) the spinal cords of 

 both cats and dogs were transected at different levels. The 

 pyrogen was administered for periods extending from 8 to 6I days. 

 The pyridine -silver method was employed for staining sections 



Histologic evidence of new growth of neurons into or across the 

 cut was secured from the cords of animals living 42 days or 

 more. Some connective tissue scarring and the usual amount of 

 retrograde degeneration were observed. There appeared to be no 

 barrier of- glial tissue, but a blending of the connective tissue 

 with the parenchyma of the spinal cord. Through such areas, 

 the nerve fibers could be seen growing into the scar. Numerous 

 blood vessels were seen at the scar-cord junction; macrophages 

 were numerous in the spaces between strands of non-nerve cellular 

 elements and the nerve fibers in the cord. Many nerve fibers 

 had penetrated the scar and there was invasion of the opposite cut 

 end. Serial sections revealed that nerve fibers were outgrowths 

 of severed or injured nerve rootS;, vascular and meningeal nerves 

 and intrinsic cord neurons. No functional regeneration was 

 obtained. 



737. WITTICH, P. W, 



PYROMEN in the treatment of perennial respiratory allergies 



Ann. Allergy 9:502-407; 518, I95I 



Fifty patients who presented symptoms of chronic 5 perennial 

 asthma received PYROMEN when conservative procedures had not 

 proved wholly successful. All received careful study as to 

 offending allergens, and many were under immunization therapy 

 or on elirainatory diets. Subfebrile dosages of 0.5 gamma 

 initially were increased as indicated by response. Oral therapy 

 gave variable results and was abandoned in favor of intravenous 

 measures for the most part; a few instances occurred where oral 



