265 



-19 5 1- 



therapy appeared to sustain clinical improvement established 

 previously by intravenous dosage c 



Good results were obtained for 12 patients and 18 others re- 

 ported lessened severity and frequency of attacks. The disap- 

 pearance of fatigue was notable. There appeared to be a more 

 complete response to bronchodilators and vasoconstrictors after 

 PYROMEN therapy. Twenty patients were unbenefited. While 

 therapeutic results were less rapid than those seen after ACTH 

 or cortisone therapy, the side effects were relatively few and 

 far less hazardous. The use of PYROMEN as adjuvant to other 

 measures for the control of asthma is indicated. 



738. ZINDLER, Go A. 



Pyromen therapy in the treatment of food allergy 



Ann. Allergy 9:49^-501, 1951 



A large group of patients (125) with varied types of allergies to 

 foodstuffs received subfebrile doses of PYROMEN intravenously. 

 Initial amounts injected ranged from 2.0 to 3.0 gammas; gradu- 

 ated amounts were then administered until benefits were evident. 

 Intradermal administration of PYROMEN was effective in a schedule 

 of dosages over the same range.. Sublingual administration was 

 effective when accompanied by booster doses, given by either the 

 intradermal or intravenous routes. Oral dosage ranges were 50 

 to 100^ above parenteral. Results were most satisfactory where 

 control of the offending allergen accompanied the administration 

 of PYROMEN. Tolerance was shown by the return of the ability to 

 accept a general diet without untoward reactions. Increases in 

 appetite and gains in weight were noted even where qualitatively 

 restricted diets were prescribed. 



739. ZYKINA, E. S. 



Razvitie likhordochnoi reaktsii pri vvedenii plrogennykh veshchesh 

 u normal' nuiu 1 defferentiro vannuiu konechnostl (Development 

 of febrile reactions during Injection of pyrogenous substances 

 into the normal and deferentectomized extremities) 



Piziol. zh. SSSR (Moskva) 37:186-194, I95I 



