- 1 9 5 2 - 



744. GRANT, R. and WHALEN, W. J, 



Latency of response to bacterial pyrogens as affected by previous 

 Incubation with blood 



Federation Proc. llfPt. I) 58, 1952 (Abstract) 



When small amounts of PYROMEN* (from Pseudoroonas aeruginosa ) 

 were incubated with whole blood, heparlnlzed, and injected in 

 animals, the onset of fever reactions appears to be hastened. 

 There is vasoconstriction, inhibition of polypnea, and rise 

 in rectal temperature initially, but no augmentation of fever 

 is obtained. No such effects followed the use of plasma, either 

 heparlnlzed or cltrated. No explanation for either acceleration 

 or augmenting effects seen after injection of other pyrogens 

 in cltrated plasma (LeQulre, J. Infect. Dis. 88:194, 1951) can 

 be offered at this time. It is believed that tissue "injury" 

 products are not Involved in the production of a latent period 

 before temperature increases, 



745. GUERRIERI, J. A. 



Treatment of neurodermatitis with PYROMEN - A new therapeutic 

 agent 



Clin. Med. 59:29-35, 1942 



Chronic and acute neurodermatitis, in vailing manifestations 

 and recalcitrant to treatment, has shown response to minute 

 doses of a bacterial polysaccharide, PYROMEN.* 



Fifty-two patients, in a group of 60 under treatment, had some 

 lessening or complete remission of dermatologic symptoms; im- 

 provement was shown with 1 week in conditions present for 6 

 months or less, and in 2 weeks for chronic conditions (over 1 

 year). The initial dose administered was either 1.0 or 2,0 

 gammas, and the therapy was continued, weekly or serai -weekly^ 

 for periods ranging from 2 weeks to 7 months. Remission fol- 

 lowed in 18 patients with acute forms of neurodermatitis and In 

 8 with chronic dermatoses. The remissions extended longer than 

 when ACTH (or cortisone) was administered. Greater safety was 

 evident; but one febrile reaction was reported and there were 

 no undesirable side effects. No resistant exacerbations fol- 

 lowed the discontinuance of therapy. PYROMEN* may achieve its 

 beneficial action through increasing the natural defenses of the 

 dermis against local trauma or toxic invasion. 



♦PIROMEN 



