269 

 - 1 9 5 2 - 



NICHOLES, Po So and BUBEL^ H„ Co 



Increased resistance to infection by the concomitant adminis- 

 tration of bacterial pyrogen and vaccine 



Bact. Proco (Soco Am, Bacteriologists) 1952^ Po 7^ 



Pyrogen from S„ typhosa administered parenterally with B. 

 tularense significantly Increased the resistance of test anl- 

 mals to a challenging dose of a highly virulent strain of 

 B, tularense . Rabbits treated simultaneously with pyrogen and 

 vaccine (B. tularense ) produced antibodies to a greater degree 

 than did rabbits which received pyrogen or vaccine only, 



SCHOPP, A. Co, PELLHAUER^ Go Mo and EIGEL, Eo G. 



Preliminary observations on a new drug in the treatment of acute 

 poliomyelitis 



Medo Bullo Sto Louis UniVo 4 s 6-10, 1952 



PYROMEN* was administered to every second patient admitted for 

 the treatment of acute poliomyelitis during a period of six 

 months o Clinical impressions of the results of this therapy for 

 53 patients were recorded, although random selection of this 

 type does not afford opportunity for carefully controlled studies 

 Supportive treatment was employed ., for the ma,5ority of these 

 patients o The usual dose of PYROMEN* ranged from 3oO to 3oO 

 gammas, administered twice daily „ More intensive therapy was 

 employed In a few cases; in one, a child 17 months old, a single 

 massive dose of 80 gammas was administered without harmful 

 effects o A direct relationship could be noted between early 

 reactions to the drug and the therapeutic benefits achieved. 

 Reactions were varied; fever, chills and myalgia appeared most 

 frequently; extreme lethargy was noted in a few patients. These 

 symptoms of reaction disap'peared early and no after effects 

 were apparent » 



While mortality was not appr«clAfe3.7 altflU?*^' byf the administra- 

 tion of PYROMEN*, marjy beneflalt^i rea«lt» f^lO^^ed treatment. 

 In spinal paralytic par«lysii8, apattia, and itfl tecompanying 

 pain, was relieved o Residual aparfelclty w|^l«^ft oft«n ,ob--i'S?-^^^^ 

 served o The most dramatic rtPtpYifJj^llfSocct^e^ri^^ 

 involvement, where complete reVet-aal of the clinical picture of 

 acute Illness was observed o While the 7 deaths reported were 

 those of patients with bulbar poliomyelitis, the PYROMEN-treated 

 group included patients with the most serious aspects of this 



♦PIROMEN 



>■':.. 



