270 



- 1 9 5 2 - 



form of the disease o The drug appears to exert its most 

 pronounced effects where higher centers of the central ner- 

 vous system are affected. The duration of acute illness is 

 materially shortened. The drug appears to be safe for use 

 and merits further study in the treatment of acute poliomyelitis, 



748. SCOTT, D.j JR. and CLEMENTS, C. D. 



Mechanism of spinal cord regeneration in the cat 



Federation Procc 11 (Pt, I) 143, 1952 (Abstract) 



A second factor is involved in neuronal regeneration in the 

 spinal cord of the cat following treatment with PYROMEN*, since 

 a small number of animals have failed to show significant 

 regeneration after treatment. When, at the time of cord 

 resection, the distance separating proximal and distal stumps 

 of the cord were measured and the proximation compared with 

 results after PYROMEN* treatment, it was found that when the 

 distance was 1 mm. or less between the two sections of the cord 

 at operation, active regeneration followed with transmission 

 of potentials to 25 to 30 per cent of normal. No regeneration 

 was seen beyond the site of the lesion when the separation 

 was 2 ram. or more. It is believed that both treatment with the 

 bacterial polysaccharide PYROMEN*and close proximation of the 

 two cut ends are necessary for successful regeneration of 

 spinal cord neurons in adult cats. 



749. SEIBERT, P. B. 



Introduction, Symposium on bacteriaX p yrogens 



Tr. New York Acad. Sc. 145I57-I58, 1952 



The nature of 'true' pyrogens has not yet been fully estab- 

 lished, vniile it is believed that many of the pyrogens are of 

 carbohydrate structure, the polysaccharides of certain or- 

 ganisms, e.g. the tubercls bacillus, do n6t produce tempera- 

 ture increases, while protein fractions are pyrogenic. It would 

 appear that the purified polysaccharides of tuberculin and of 

 the parent bacillus are not pyrogens. "The isolation of a 

 pure and stable pyrogen, with well-defined chemical and bio- 

 logical properties which could be easily reprotSuced, would 

 furnish a valuable standard for the evaluation of pyrogen in 

 products for intravenous use." 



♦PIROMEN 



