- 1 9 5 2 - 



degree of leukocsrtosls thereafter. The leukocytosis is accom- 

 panied by a depression In the number of circulating lymphocytes 

 and eosinophils and often, by an Increased body temperature. 

 In the cat, leukopenia Is accompanied by a rise In the plasma 

 ascorbic acid level. 



Administration of the polysaccharide preparation produces histo- 

 logic changes; hyperplasia of the thymus, lymphatic and splenic 

 corpuscles; depletion of the lymphocyte population of peribron- 

 chial tissue and of the tumlca propria of Intestines; and re- 

 duction of cytoplasmic droplets in the fascicular zone of 

 adrenals and follicular colloid of the thyroid gland. The bone 

 marrow was not studied. In the cat and rabbit, treated dally 

 or three times weekly for 10 to 120 days with a polysaccharide 

 from Pr. vulgaris , certain changes reminiscent of rejuvenation or 

 reversal to the fetal state appeared in lymphoid tissue, the 

 reticuloendothelial system and the endocrines. There was no 

 evidence of the type of pathology seen in true stress. 



Endocrine mechanisms appear to be affected by FYROMENt Chronic 

 bilateral adrenalectomy in cats abolished the minimal PYROMEN* 

 response; transplantation of adrenal cortical tissue revived 

 it. Toxicity was increased for the adrenalectomlzed animal. 

 Hypo phy sec tomy altered the degree of response, reduced the 

 leukocytosis which follows. Thyroidectomy delayed the onset 

 of leucopenla and leukocytosis and ovarectomy produced a similar 

 picture. Estrus, pregnancy and lactation produce variations In 

 the response to PYROMENt 



The enhancing of the healing process in skin burns by PYROMEN* 

 may be related to an increase in the permeability of connective 

 tissue. The most dramatic activity of PYROMEN* to date has 

 been its striking inhibition of glial barriers in the transected 

 spinal coi»d and the regrowth of neural fibers across the 

 approximated severed ends. Recent experiences have shown that 

 glial barriers against the growth of peripheral nerves may be 

 inhibited in brain tissue* 



755. WINDLE, W. P. 



Regeneration in the spinal cord 



J. paraplegia 2:3-5> 1952 



In a discussion of the therapeutic implications inherent in the 

 discovery that prevention of glial overgrowth at the site of 

 resection of the spinal cord follows the use of PYROMEN*, the 

 author lays emphasis upon the fact that the application of these 



♦PIROMEN 



