19 5 2 



Some improvement was noted in k of 22 patients with multiple sclerosisj 

 spasticity appeared to be benefited in late stages of the diseasej such 

 improvement may have a subjective basis. The dosage of PIROMEN may be 

 a determining factor in these conditions. Work, still unpublished, would 

 indicate a possible therapeutic role for the drug in the treatment of 

 encephalitis of allergic origin if results of experiments now in progress 

 confirm early observations. At this time, much more study of the efficacy 

 of this preparation is needed before its value in treatment of crippling 

 neurologic disease can be evaluated. 



772. FRACCHIA, A. A. and BRUNSCHV7IG, A. 



Hyperthermia (lli|-F Rectal) with recovery 



J.A.M.A. lU9:926-927, 1952 



Intravenous injection of Coley's toxin (0.12 ml. to 1.^4-8 ml. daily for a 

 ten-day period) produced symptoms of mental confusion, facial congestion 

 and cardiac arrhythmia, accompanying a temperature reading (rectal) of 

 11^4-°?. Administration of antipyretics, 5f" dextrose solution and other 

 temperature -reducing measures brought a rapid drop to 10U° F. within I5 

 minutes. The patient exhibited no ill effects from this brief period 

 of hyperpyrexia. Inactivity of an extensive ovarian carcinoma for 17 

 years^ after surgical procedures and Coley's toxins had been employed, is 

 confirmed. 



775. GINGER, L. G. and WINDLE, W. F. 



Studies on the chemistry and physiological action of bacterial pyrogens 



Second International Congress of Biochemistry, Paris, July 21-27, 1952, 

 Resume' of Communications, Sec. 28, pp. kk-^-hk6. 



Significant differences may exist between pyrogens obtained from different 

 bacterial species. Minimum pyrogenic doses from nonprotein concentrates 

 prepared from B. subtilis, S_. marcescens, a Pseudomonas species, E. coli, 

 Proteus vulgaris and S. typhi , ranged, in the rabbit, between 7.5 and 0.22 

 gamma, per Kg. body weiglit, and were unrelated to the polysaccharide content. 

 A new fraction from Pseudomonas species was a highly pyrogenic, electro- 

 phoretically homogeneous substance (FC-k) which may represent the pyro- 

 genic factor. It appears to be a stable polysaccharide-amino acid-lipid 

 complex, in which the polysaccharide component consists of hexosamine, 

 an unclassified reducing sugar and a nonreducing carbohydrate. PIROMEN 

 toxicity is slight (LD50 60,000 in the mouse) and dosages above 1000 

 gamma have been given to animals without toxic manifestations. At dosages, 

 for man and animals,. of O.O5 - 0.5 gammas/kg., early granulocytosis, 

 hypertrophy of the thymus, and lymphatic system, release of thyroid colloid 

 and adrenocortical secretions followed within 2 to 5 days. Chronic adrenal- 

 ectomy abolished the leukocyte response and the latter could be revived 

 by adrenal cortex transplantation. Burn healing was enhanced, with natural 

 debridement and edema reduction. PIROMEN prevented formation of pia-glial 

 scars in spinal cords after resection and permitted neuronal regeneration. 



