295 



19 5 2 



17k. NE>ffiLL, F. W. 



Fever therapy in ophthalmology today 



Qtly. Bull. Northwestern U. M. School 26:151-156, 1952 



Dramatic response of inflamed tissues of the eye follows hyperpyrexia, 

 induced by either passive agents, or by parenteral injection of pyrogenic 

 substances. The present status of fever therapy in ophthalmology is re- 

 evaluated with a view to clarifying the roles of heat, immunologic response 

 or "trigger" activity on the adrenocortical system, in the reduction of ocu- 

 lar inflammation. If the initiation of stress underlies the beneficial 

 effects secured through the use of bacterial pyrogens, it is believed that 

 such results can be most easily obtained by administration of ACTH and 

 cortisone. The use of bacterial pyrogens is well- justified, however, if 

 it is confirmed that other important activities follow their application in 

 ophthalmology .. 



775. PEARIMAN, M. D. 



Management of endogenous uveitis 



Eye, Ear, Nose and Throat Month. 31:202-206, 1952 



Nonspecific fever therapy has been effectively used in the past for the 

 therapy of inflammatory ocular disease. Typhoid vaccine and the bacterial 

 extract PIROMEN are the most effective pyrogenic agents now in use. "Milk 

 and its protein derivatives, proteolac and omnadin, are less effective." 

 The mode of action of these pyrogenic substances has not yet been definitely 

 ascertained; the most recent theory presented would assign a stress-pro- 

 ducing activity to these materials "thereby stimulating an ACTH and corti- 

 sone response." 



776. POEL, W. E. and BELKIN, M. 



Variations in eosinophil morphology and leukocyte counts in the rat follow- 

 ing injection of a tumor-necrotizing bacterial polysaccharide 



Am. J. Physiol. l69:lj-53-i^59, I952 



Leukocytosis and lymphopenia which follow the injection of bacterial poly- 

 saccharides suggest adrenal cortical activation. To observe more fully 

 the changes in circulating leukocytes, particularly alterations in the 

 eosinophil ratios, the polysaccharide of Shear (P-25) was injected in 

 the rat in dosages equivalent to 5 gammas per Gm. body weight. Changes 

 in the hematologic picture were compared with those seen after the in- 

 jection of saline solution. Leukopenia of both neutrophils and lympho- 

 cytes appeared in the first hourj leukocytosis followed. The elevation 



