19 5 2 



in leukocytes persisted approximately 2k hours. Eosinophil levels 

 followed a "W" pattern when plotted graphically, peaks corresponding to 

 k, 6 and 12 hours after injection. Eosinophil structvire was altered) frag- 

 mented, pyknotic and granulocytic cells were seen. At the 6 hour "peak" 

 the transient recovery observed appeared to correspond either to an exhaus- 

 tion or a mobilization phase; marked eosinopenia followed such recovery. 

 Adrenocortical or unknown factors may initiate alterations. 



777. SAMIER, M. and KOFOED, M. A. 



On the rationale of treating allergic diseases with bacterial pyrogens 



J. Allergy 25:527-35^, 1952 



In comparison with a placebo, the clinical effectiveness of PIROMEN, when 

 given in a limited dosage range, for the therapy of anaphylactic allergies 

 (rhinitis, bronchial asthma, and urticaria) was no greater than a corres- 

 ponding araount of its solvent. The compound was found to have low anti- 

 genicity for manj it affords no demonstrable inhibiting effect on the 

 formation and distribution of anaphylactic antibodies in the experimental 

 animal. 



77S. SCOTT, D., Jr. and CLEMENTE, C. 



Conduction of nerve impulses in the regenerated fibers of the spinal cord 

 of the cat 



A.M.A. Arch. Neurol, and Psychiat. 67:850, I952 



Adult cats were permitted to recover without treatment following resection 

 of the spinal cord or were treated with PIROMEN for periods ranging from 7 

 to 17 months. Electrophysiological studies were confirmed by histologic 

 examinations. Stimulation of the pyramidal tract fibers above the site of 

 the lesion evoked nerve impulses below the site of resection after treat- 

 ment with the bacterial polysaccharide; the two factors which affected the 

 extent of regeneration were (1) administration of PIROMEN and (2) close 

 proximation of the proximal and distal portions of the cord after section. 

 Corticotrophin appears to have similar activity while cortisone blocks its 

 effectiveness. 



779. WALTON, C. H. A. and ELLIOTT, G. B. 



Sudden death from bronchial asthma following injection of PIROMEN 



J. Allergy 23:322-526, 1952 



In an asthmatic female, age 51^ with a stormy history of severe paroxysmal 



