297 



19 5 2 



asthma complicated by hypertension, toxemia and transient psychotic 

 episodes, control of asthmatic symptoms had been possible through the use 

 of epinephrine, isuprel, aminophyllin and ACTH. PIROMEN \ms administered 

 for one week before death, producing only sli^t shivering in dosages rang- 

 ing between 1 and 5 gammas. Temperatiire elevation was registered after 

 the first 5 injections only. No immediate reaction occurred after the 

 last injection of PIROMEN, but asthmatic symptoms were not benefited. 

 Dyspnea increased, epinephrine in repeated dosage brought no relief. Deep 

 cyanosis and death followed. On autopsy, intense bronchial sind bronchiolar 

 obstruction, due to mucus plugging and edema, was seen. Bronchopulmonary 

 lymph nodes were enlarged, but all others appeared normal in size. A per- 

 sistent thymus was foiind. The lungs were crepitant. Congestion of both 

 brain and pituitary was seen. It was not possible to link the administration 

 of the medication (PIROMEN) with the terminal asphyxia. "Asthmatic patients 

 of this type have a notoriously bad prognosis and often require very little 

 to upset their delicately balanced respiratory state..." 



AUTHOR INDEX (TO ADDENDUM) 



