360 



PYEOGENS 



effects . on thermoregulatory 

 centers, 577; of removal of 

 adrenals and thyroid, 6kk, 6k^; 

 of temperature on reactions 

 to, 57^;- 579; inhibitory, 614-3; 

 on hunger and appetite (dog), 

 "Jk; on the lymphatic system, 

 773; on nitrogen and piArine 

 metabolism, 125; on gastric 

 secretion, 5^0^ 596 



elimination, 16^^, 583, 592; by 

 adsorptive filtration, 238, 

 250 ; by hydrogen peroxide, U2I, 5^8, 

 719; from solutions of strepto- 

 mycin salts, 655; emergency, from 

 vater, 30^; detailed methods for, 

 23l<-; from serum, plasma, hemo- 

 globin solutions, 509; from 

 hormones, viruses, toxin- 

 antitoxin preparations, 570; 

 in solution manufacture, 558; 

 review of methods, 505, 507,5^1 



endotoxin, presence depends on phos- 

 phate attachment to hexose or 

 protein component, 758 



exudates, thermostable leulcocytosis 

 factor, 663; euglobulin fraction 

 in inflammation, 597 



hijmic acid (decomposed hay) as, 202 



hypothalamus, control over reaction, 

 289, 307; section, blocks pyro- 

 genic activity, U03 



hypertension, reduction of blood 

 pressure after, 338, 397 



inulin, dahlia, adsorption, 252; 

 renal hyperemia not neiirally 

 controlled, 314-8 



literature, review, 2814- , 575, 705 



milk, source of, 814-, 88. See also: 

 Pyrifer 



nucleiis, components, source, 379 



production, 278, 379; in gum 



acacia, 278; in protein sol- 

 ution, 107 



Proteus vulgaris , as source. See: 

 Piromen, Polysaccharides and 

 under name of bacterium 



Pseudomonas aeruginosa , as source. 

 See: Piromen, Polysaccharides 

 and under name of bacterium 



Pyrifer, as source. See Pyrifer 



reactions after administration, 

 cause and elimination, 205; 

 after deference tomy, 739; 

 diminished by barbiturates, 

 722; at injection sites, 726; 

 after transfusion. See Trans- 

 fusions, blood, under Pyrogens; 

 prevention, 205, 652 



renal changes, 314-8, 397, 682 



Serratia marcescens as source of, 

 14-38. See -under; Poly- 

 saccharides and under names of 

 bacteriimi 



solutions, as so\irce,107, III+, l61l- 

 205, 206, 213, 23!^, 238, 2I4-6, 

 276, 370, I4-OI1, I4-82, I4-93, 501 

 571, 599, 610, 62U, 633, 635, 

 652, 700, 711 



decline in, during 



storage, ll-82, U93, 5OI, 571, 

 634 



depyrogenation, U.S. P., 



514-8; preparation, 3IH, 14-14-2, 



457, 1+59 

 term, coined to cover all fever- 

 producing agents, 9 

 tests, U7^, 592, 628 



animals used should not be res- 

 strained, 6I4-3 



based on leukocytosis of rabbit, 

 for injectable solns., 633 



chemical, for distilled water, 

 160 



detection in fluids by bio- 

 logical methods, 389 



evaluation of biological and 

 chemical tests for, 379 



for missed contaminations in 

 biological products, role of 

 cryophile bacteria, I4-87 



in aqueous solns. methods, l4-Ol4- 



investigations on tests for 

 injectable solns., 699 



methods, 14-71*- 



methods for large scale testing 

 ■tn rabbit (thermocouple box), 

 kk& 



on non-pyrogenic fluids, 1158 



quantitative assay method in 

 rabbits, 602; def. of indice^701 



search for reliable sensitive 

 method for determination of 

 pathogenicity in rabbits, 

 leulcocyte response, 14-17 



