6 ART. 7. 1. IJIMA. 



thigh, I should consider it a moderate estimate to allot on an 

 average one capsule to every 20 sq. mm. of such cut surface or to 

 every 100 cu. mm. of the infested tissues. This would give 1000 

 capsules to a mass of 100 cu. cm. of the same, in other words, to 

 a mass of the subdermal tissues represented on the skin-surface by 

 an area of 25 sq. cm., assuming the depth to be 4 cm. At any 

 rate, I believe it to be in no way an exaggeration to say that 

 there must have been considerably over ten thousand capsules in 

 the left thigh alone. 



Worms tvithout Capsule, — Here I may mention that not 

 all the worms were found in the encapsuled state. During the 

 surgical operation a number of them were discovered free, so to 

 say, in the connective tissue. This mode of occurrence was 

 placed beyond doubt by observations of cases in which some 

 worms, with moderately extended body and without a trace of an 

 enclosing capsule, were found lodged right within a ßlm of the 

 fresh connective tissue when the latter was carefully distended 

 between the fingers. It is noteworthy that these frec^ worms were 

 always small and of the simple slender shape, — typical Plero- 

 cercoids such as those represented in fig. 2 a-c ; they were never 

 so plump-bodied as are many confined within capsules. This fact 

 indicates that it is only the comparatively younger individuals 

 that are sometimes found free in the connective tissue. 



Movements of the Worm; the Head. — Living worms lib- 

 erated from the capsule by cutting this open and left in the warm 

 lymph, showed slow movements, alternately extending and con- 

 tracting, but effecting little or no change in position. On cooling 

 the movements subsided, leaving the worm in a more or less 



