I9I0.] WORK ON NUTRITIVE PROCESSES. 163 



in amount. Particularly is this the case with those who are de- 

 siring to reduce the body weight. It is sometimes amusing to 

 think of people who are going through all kinds of muscular 

 exercise to work off their fat and at the same time these muscular 

 exercises are stimulating a most voracious appetite which must be 

 appeased. In my judgment, instead of decreasing the consump- 

 tion of food to reduce the fat of the body, it is better to produce a 

 feeling of satiety and thus cut down the ravenous appetite. This 

 can, I believe, best be done by more frequent small meals than by 

 leaving out any one meal and eating to complete satiety at the 

 others. 



I have outlined to you very hastily this evening a few of the 

 important problems that we are able to study by means of the respir- 

 ation calorimeter. These researches that I have thus far outlined 

 were carried out in the chemical laboratory of Wesleyan University 

 and it may be of interest to you to know that the researches were 

 deemed so important that a special laboratory has been constructed 

 for their prosecution in Boston- — ^the Nutrition Laboratory of the 

 Carnegie Institution of Washington — where it is hoped to study 

 more accurately the questions relating to health and, indeed, to 

 disease. The laboratory is located near the Harvard Medical School 

 and in the vicinity of a large number of hospitals which are either 

 built or are planned. In this way we hope to be able to get into 

 most intimate touch with pathological material. 



At Wesleyan University only one calorimeter was used for all 

 the different kinds of experiments, but in the new laboratory three 

 calorimeters are already completed and two others projected, thus 

 providing an apparatus which will be particularly adapted to the 

 kind of experiment planned. In the chair calorimeter a large num- 

 ber of experiments have already been made with diabetic subjects, 

 and the bed calorimeter has been used for studying bed-ridden 

 patients, not only for those having diabetes but a most interesting 

 series of observations have also been made on women before and 

 after confinement. The laboratory is also thoroughly equipped for 

 studying all the excreta and many problems involving muscular 

 work. 



