1877.] oJ7 [Haynes. 



and five grains of nicotin. It died in forty-three minutes, with peculiar con- 

 vulsions. 3. A frog, placed in a solution of strychnia (five grains to five 

 ounces of water;, was immediately seized with tetanic convulsions, and died 

 in four minutes. 4. A frog, placed in a solution of strychnia (five grains to 

 twenty ounces of water), became speedily convulsed, and died in fifty-five 

 minutes. 5. A frog, placed in a bath containing nicotin and strychnia (of 

 each five grains to ten ounces of Avater), remained there nineteen minutes 

 without any inconvenience, when it was seized with tetanic convulsions, 

 which continued, but with less violence than in the previous experiments. 

 After forty-seven minutes, the animal was I'emoved, and washed in cold 

 water. It lived afterwards more than twenty-four hours, exhibiting at 

 intervals tetanic convulsions. 6. A frog was placed in a bath of nicotin and 

 strychnia, as in the last experiment, and removed after ten minutes. In 

 forty -two minutes, tetanic convulsions appeared, and continued for many 

 hours, but they were succeeded by perfect recovery. 



Wormley's Experiments. To each of thirteen cats, one-half grain of 

 stiychnia was given. " The poison was passed in solution into the stomach, 

 by means of the stomach-tube. In some instances, as soon as symptoms of 

 poisoning appeared, an infusion of twenty grains of tobacco leaves was ad- 

 ministered, in the same manner as the poison ; while, in others, the tobacco 

 infusion was given along with the strychnia, the two infusions being 

 thoroughly mixed. In some few cases, the dose of tobacco was repeated. 

 As the result of these experiments, one of the animals, which had taken 

 the mixed solutions, immediately fell prostrate, breathed with difficulty, in 

 three minutes voided urine, in eight minutes vomited a frothy mucus, and 

 in ten minutes was able to run, with, however, a stiff* gait. After an hour, 

 the animal appeared perfectly well, with the exception of a slight stiffness 

 in walking. With this single exception, all the animals died, and, in most 

 instances, within the usual period. One of them, however, that had taken 

 the mixed solutions, manifested no symptom whatever, for thirty-five min- 

 utes. In some instances, the strychnine symptoms appeared to be not in 

 the least aifected by the tobacco. But, in others, they were of a compound 

 nature. Several of the animals vomited. Before performing these experi- 

 ments, it was ascertained that an infusion of twenty grains of tobacco, given 

 alone, would produce serious symptoms ; but, in uo instance, in six experi- 

 ments, did it cause death." — [ Micro-C/iemisiri/ of Poisons, liiew York, 1865, 

 p. 545.) 



Reese's Experiments Avere made on dogs. The drugs were, as a rule, given 

 by the mouth. 1. Three-fourths of a grain of strj^chnia, hypodermically, 

 killed a moderate sized dog, in nine and one-half minutes. 2. Thi-ee-fourths 

 of a grain of strychnia, and two drachms of a concentrated infusion of 

 tobacco, were given by the mouth. Twenty- six minutes, tetanic spasms ; 

 thirty-one minutes, non-tetanic spasm ; thirty-three minutes, somewhat 

 tetanic spasm ; thirty-nine minutes, one-half drachm of infusion of tobacco 

 was given hypodermically, and was immediately followed by a tetanic 

 spasm, and death. 3. Two drachms of tobacco infusion. Five minutes, free 



PROC. AMER. PHILOS. SOC XVI. 99. 3w 



