Ilaynes.] 



600 



[March 16, 



Table I. 



Showing the Effects of Nicotin on Rats, tind indicating the Minimum 



Lethal Dose. 



No. 



1 W/i oz. 



IfM oz. 



10 



II 



12 



13 



14 

 13 



&/ioz. 



W/i oz, 



lOVi oz. 

 8 oz. 



11 oz. 



61^ oz, 

 8^oz, 



1014 oz. 

 10 oz. 

 10 oz. 



11^ oz. 



lOVi oz. 

 8 oz. 



4)4 oz. 

 W/i oz. 



1-1000 Recovery 



1-800 



1-700 



1-666 



1-600 

 1-600 



1-5.50 



1-500 

 1-440 



Recovery 



Recovery 



Recovery, 



Recover}- 

 Death . 



Recovery . 



Recoverj' , 

 Recovery. 



Syjiptoms. 



1-100 Recovery 

 l-;!00 Keeovory 

 1-230 Recovery 



1-2.30 



1-230 

 1-230 



1-200 

 1-194 



Recovery 



Recovery 

 Recovery 



Death. 

 Death. 



Ran around the room actively for 5 minutes, 

 then loss actively till 10th min.; after which lay 

 <)Uiot unless itisturbotl, when it ran, but with ilitli- 

 eulty. Ilospiration, after 'jth min., tlillicult— the 

 walls of tlie chest exhibited a greater extent of 

 motion than usual. Could be handled, without 

 biting. 37 niiti.. recovering. 



Immediately lay quiet and breathed laboriously, 

 and after the 6tli mm. noisily. At intervals, slight 

 convulsive movements. At no time was there in- 

 ability to move when disturbed. 13 min., recover- 

 ing. 



After '1; min., lay quietly, breathing laboriously. 

 I >ni)t., ca'n barely move when disturbed. Respira- 

 tion noisy, and slower than normal. S^^ min,, res- 

 piration gasping, .58 a minute. 22 miti., respiration 

 still labored, .SO ; moves more readily. 



Panting respiration, and semi-paralysis. Re- 

 covery after 30 min. 



Same as in last cxi^eriment. 



After 15 .syv., hissing and laborious respiration ; 

 moved rapidly around the cage till 40.vec.; then lay. 

 gasping for breath, till 60 .^ec, when tetanoid con- 

 vulsions occurred, which caused respiration to 

 cease at the end of the I'd min. 



y, min., (\ilWcu\t I'espiration. 1 »)n'n., paralysis. 2)4 

 mill., clonic convulsions with opisthotonos, whiclii 

 continued at intervals till .S//( min., when they 

 ceased, and the respiration became gasping and 

 infre(iuent. lo per minute; and there was com- 

 plete motor paralysis. 12 min., respiration re-estab- 

 lished, hissing. .35 min., slight voluntary move- 

 ments. ()i) min., almost constant convulsive trem- 

 bling, Willi laborious and occasionally noisy res- 

 piration. 2 /ir.f. conilition the same. Very slight 

 movements occasionally. 



.Same as in last experiment. 



Immediately dillicult respiration. H min., vio- 

 lent tetanic convulsions, succeeilcd ijy panting 

 noisy respiration, anil complete motor" paralysis. 

 \'ery rai)id muscular quiverings, causing such ra- 

 pid movements of one foreleg that they could 

 scarcely be seen. 19 min., recovering voluntary 

 power. 



Usual symptoms. Convulsions clonic and tonic. 



Usual symptoms. Convulsions clonic. 



Difficult respiration, slight clonic convulsions, 

 iind semi-paral.vsis. 



j Dillieull respiration, no convulsions, senii-pa- 

 jralysis. 

 ' Same as in last experiment. 



Dirticult respiration. 3'.,' ntin., violent tetanic 

 ;convulsions, after which respiration ceased for 15 

 sec, then recommenced with a gasp. There was 

 semi-paralysis for a i'ow niinutes, but by LS min. 

 jthe aninial had almost recovered. 



1 Immediatel.v clonic convulsions, which ended 

 fatally in ' ^ min. 



Kan aroim'd the room for |.j wkji., when he stopped, 

 and the respiration was not'ed nois.vantl laborious. 



2 min., complete motor paral.vsis. 3'o min., violent 

 clonic convulsions lasting till 4'^ »»(»'. Respiration 

 now ceased till 5'^ min., recommenced with a gasit, 



land ceased finally at (J min. 



