1877.] 



601 



[Haynes. 



Table I. — Continued. 



No. 



18 



Weight 

 of Rat. 



19 



20 



21 



7^02. 



IQi/g oz. 

 914 oz, 



7%oz, 



1-176 



1-176 



1-143 



1-143 



Result. 



Death. 



Recovery 



Death. 



Death. 



Symptoms. 



1^ mm., convulsions, succeeded by difficult respi- 

 ration and semi-paralysis. 25 )7iin., complete pa- 

 ralysis. 214 hrs., moves limbs slightly when dis- 

 turbed. Death at 3 hrs., the respiration falling 

 gradually down to 6, then to 1, per minute. 



1 min., labored respiration. 4 min., prolonged te- 

 tanic convulsion, followed by the usual respira- 

 tory difficulty and semi-paralysis. 60 min. recov- 

 ery. 



}4 min., noisy, labored respiration ; convulsions, 

 lasting 3 min., then almost complete paralysis. 

 53 min., convulsions excited by slight irritation, 

 semi-paralysis till 144 min., when slight voluntary 

 motions were noted. 20 hrs.. respiration feeble, 30; 

 lay powerless on the side, and had tetanicand clon- 

 ic convulsions when disturbed. '20}4 hrs., heart 

 beats, 93 ; respiration, 15. Entire paralysis. 23 hrs., 

 death from failure of respiration, which had oc- 

 curred once a minute for some time previously. 



Same as in last experiment. Death after 5 hrs. 



III. Effects of Nicotin and StrycJinia Sulphate, when Injected Simul- 



taneously. 



First, the drugs were injected in less than fatal doses ; next, fatal doses 

 were employed. 



Table II. 



Strychnia St(,lphat6 and Nicotin, injected simultaneously, in Non-fatal 



Doses. 



Results. 



Ran around the room actively 

 for 4 min., then kept quiet, un- 

 less disturbed, for J^ hr. During 

 this time, the respiration was 

 panting. 



After 1 min., difficult respira- 

 tion and prostration. 8 min., 

 almostcomplete paralysis, con- 

 vulsive motions occasionally. 

 Increased reflex excitability. 

 27 min., recovering. 



Difficult respiration, increas- 

 ed reflex excitability, and indi.s- 

 position to move. 



Very difficult respiration, and 

 semi-paralysis. The animal 

 had scarcely begun to recover 

 at the end of 45 min. 



Result of Crucial Experi- 

 ment performed Nine 

 Days afterwards. 



Strychnia Sulphate gr. 

 1-96, alone, produced no 

 eflTect. For the effect of 

 111 1-1000 Nicotin see Ex- 

 periment 1. 



Strychnia Sulphate, gr. 

 1-96, alone, produced a 

 slight increase of reflex 

 excitability. For effects 

 of Nicotin, 111 1-800, see 

 Experiments 1, 2, and 3. 



Strychnia Sulphate, gr. 

 1-64, produced slight in- 

 crease of reflex excita- 

 bility. 



Nicotin, 111 1-666, pro- 

 duced difficulty of respi- 

 ration and semi-paraly- 

 sis lasting 30 min. 



