Haynes.J 



602 



[March 16. 



Table II. — Continued. 



No. 



26 



27 



28 



29 



Weight 

 of Rat. 



11 oz. 



8 oz. 



•ct. . 



o a ^ 



•Si 



llVi oz, 



WM oz, 

 101^ oz, 





1-96 



■i. 



1-100 



1-96 1-230 



1-96 



1-96 



1-96 



1-230 



1-230 



1-176 



Results. 



Immediately, difficult respira- 

 tion and ainio.st complete paral-' 

 ysis; tiicn convulsive trom- 

 bling. At 11 mill., violent con- 

 vulsions, after which there \v;is 

 semi-paralysis, with very diffi- 

 cult respiration. 



\4 min., panting respiration,' 

 and almost complete paralysis. 

 21^ min., convulsions, whicli re- 

 curred every few seconds til I the 

 5lh min. They were .sometimes 

 clonic, and sometimes tonic. 

 The animal lay (|uiet till the 

 llth min., when there was an- 

 other convulsion. V.imin., con- 

 vulsion, marked reflex excita- 

 bility. 05 min., slight convul- 

 sion. 



1 min., panting respiration, 

 semi-paralysis. IJ^ /»;'«., violent 

 convulsions, after which rcspi- 

 raticni temporarily ceased, then 

 recommenced witli a gasp. Pro- 

 longed exhaustion. 

 Same as in E.xperiment 23. 



Re-tult of Crncial Experi- 

 ment performed Nine 

 Days afterwards. 



Nlcotin, m 1-400, pro- 

 duced difTicult respira- 

 tion, semi-paralysis, and 

 convulsions. 



Nicotin 111 1-230, was 

 followed by difficult res- 

 piration and powerful te- 

 tanic convulsions. At 18 

 min., entire recovery. 



Nicotin, 111 1-2:M. cau.sed 

 ditricult respiration and 

 semi -paralysis, but no 

 convulsions. 



1 min., irregular convulsions, 

 followed by difficult resj)iration 

 and prostration. .'!.j »ti/)., severe 

 irregular convulsions, followed 

 by marked increase of reflex 

 excitability. 7'^ min., marked 

 tetanic convulsion. 2'^ hrs., 

 there have been occasional con- 

 vulsive movements, but at no 

 time paral.vsis. 



' Nicotin, ITI l-'m, pro- 

 duced same eflJects as in 

 Experiment 28. 



Nicotin, m 1-176, had 

 been given alone 1 week 

 previously. It had caused 

 severe convulsions, but 

 theauimal had recovered 

 in 1 hr. 



The effects of fatal doses of Strychnia Sulphate, injected with, or fol- 

 lowed by, varying doses of Nicotin ; and of fatal doses of Nicotin, injected 

 with, or followed by, varying doses of Strychnia Sulphate, were next noted. 

 The results are given in the following table. It will be noticed, that in 

 some cases either drug was given in divided doses, and that, in these cases, 

 the total amounts given are mentioned in the appropriate column. 



