1877.1 



603 



[Haynes. 



Table III. 



Experiments in which Nicotin and Strychnia Sulphate were given together, 

 or at short intervals, Fatal or nearly Fatal Doses of either Drug being 

 employed. 



No. 



31 



32 

 33 



34 

 35 



36 



Weight 

 of Bat. 





O -o ^ 



37 



38 



39 

 40 



41 



8 oz. 



5 oz. 

 9>^oz. 



93^02. 



6%oz. 



5%oz. 



QJ^oz. 



6%oz. 

 9?^oz. 



lOJ^ oz, 



1-48 



1-48 

 1-44 



1-48 

 1-31 



1-48 



1-48 



1-48 



1-48 

 1-48 



1-48 





Result. 



1-2000 



1-1000 



Death , 



Death 



1-1000, Death. 



1-800 

 1-800 



1-500 



1-500 



1-500 



1-800 

 1-400 



1-600 



Death . 

 Death . 



Death . 



Death 



Death , 



Death. 

 Death . 



Death . 



Symptoms, &c. 



After 1 mbu the animal stood quiet, breotliing 

 with great difficulty. Occasional convul.sive jerks 

 were noted, and at 20 min. a tetanic convulsion 

 (with cniprosthotonos) and deatli. 



The animal stood quietly, breathing somewhat 

 heavily, until 30 nii/i., when there was a tetanic 

 spasm, and death. 



After 3 min., difficult respiration, and marked 

 reflex excitability. 5 min., slight convulsion, 

 after which the respiration -was slow and difficult, 

 and the animal walked with great difficulty, and 

 only when irritated. 15 and 27 min., slight con- 

 vulsions. 42 min., tetanic convulsion, and death. 



1 min., panting respiration. 5 min., increased 

 reflex excitability ; prostration. 25 min., tetanic 

 convulsion, and death. 



The animal immediately lay on side paralyzed, 

 and continued so till death, which followed an 

 irregular convulsion at 2 min. The respiration 

 was slow and gasping througiiout. 



The nicotin was given in divided doses. n\ 1- 

 1000 was given with the Strychnia Sulphate. The 

 rat stood quietly, breathing heavily until 12 min., 

 when there was convulsive trembling. An at- 

 tempt to use the hypodermic syringe caused a 

 convulsion. Nicotin, ITl 1-2000, was now injected. 

 x\t 20 min., a second tetanic convulsion occurred, 

 and immediately after Nicotin, ITI 1-2000 was in- 

 jected. At 22 7Jim., tetanic convulsion, and death. 



Immediately, almost complete paralysis, and 

 panting respiration. From ly.i to 4 min., continu- 

 ous opisthotonos, vvith exceedingly rapid vibra- 

 tions of the extremities. The respiration became 

 slower and slower; at times, intervals of 10 sec. 

 passed between the respiratory acts. 4 tnin., 

 slight convulsive motions. 7 min., slight volun- 

 tary motions. Increased reflex excitability. Con- 

 vulsions at 22, 34, and 37 min., then death. 



Nicotin given in divided doses, as detailed be- 

 low. 5 min. after injection of Strychnia Sulphate, 

 no effect was apparent, except increased reflex ex- 

 citability. Nicotin, ITl 1-1000, was injected, li) min., 

 the rat is inactive ; respiration somewhat labored. 

 Increased reflex excitability. Nicotin, ITl 1-1000, 

 was injected. The respiration immediately be- 

 came more difficult; the animal staggered, fell 

 on side, and, at 13^ jnm., had a violent tetanic 

 spasm (emprofethotonos), terminating in death. 



The animal stood quietly, breathing heavily. 5 

 m,in., almost helpless; marked reflex excitability. 

 13V< inin., tetanic spasm, and death. 



Difficult respiration, increased reflex excitabil- 

 ity, and almost complete paralysis, till 22 tnin., 

 when there was .a single tetanic spasm, and 

 death. 



'%min., difficult respiration ; stands motionless, 

 or moves with difficulty, if disturbed. 15 to 18 

 win., slight convulsions. 25 nii/i., tetanic convul- 

 sion, and death. 



