H.iynes.] 



004 



[Murch Kf, 



Table III, — Continued. 



A'o. 



42 



43 



44 



4.5 



46 



Qi5 W- 



10 oz. l-<Hi 1-220 Death. 



Result. 



TVgoz. 



6 oz. 



8J^oz. 



9>^oz. 



1-96 1-200 Death 



1-192 



1-96 



1-96 



1-200 



1-130 



1-125 



Death, 



Death 



DeatI) 



Symptoms, Ac. 



Tlu' Xicotin was first injected; immediately 

 after, dilHcnlt resiiiration, and senii-paralysis. 6 

 »u//i., irregular convulsions which terminated in 

 cessation of respiration for 15 sec, when it re-com- 

 menced with a sasi). There was now complete 

 paralysis (exceptinfi of course the heart and res- 

 piration). At 2.') mill., the animal was beginning 

 to recover power, when Strychnia Sulphate, gr. 1- 

 •6, was injected. 4:i »mi"/i., increased reflex excita- 

 •)ility. .50 min., tetanic convulsion, and death. 

 Post mortem — The heart was exposed ; it continu- 

 ed to beat for 10 min. 



Immediately, violent convulsions, lasting one 

 min., followed by temporary cessation of respira- 

 tion, which recommenced with a gasp. Almost 

 complete paralysis till 2.3 min., when the convul- 

 sions recurred, and terminated in death. 



The Nicotin was first injected; it was followed 

 in ]4 min. by a tetanic convulsion, lasting 2 min.; 

 then semi-paralysis. 4 min., Strychnia Sulphate, 

 gr. 1-192, was injected. 10 «ii?).,the semi-paralyzeu 

 condition continued. Reflex excitability increas- 

 ed. 14 min., tetanic, alternating with clonic, con- 

 vulsions commenced, and lasted for S min., after 

 whicli there was almost coni])lete paralysis 133 

 min., tetanic convulsion, and death. 



Convulsions for .5 min., succeeded by .semi-paral- 

 ysis, and increased, reflex excitability, with ex- 

 treme difliculty in respiration. 2 hrs., slight vol- 

 untary motions. '2f) ?irs., almost complete paral- 

 ysis; no convulsions. 21 /(>•«., complete paralysis; 

 slight convulsive movements occasionally. '2>hrs., 

 death from failure of respiration, which had be- 

 come very infrequent (one a minute). 



1 min., tetanic convulsion, lasting 2 »i(;i., and fol- 

 lowed by semi-paralysis and ditlicult respira- 

 tion. 28 min., tetanic convulsion, and death. 



B. Ou C'lU. 



As iu the preceding series of experiments, the minimum fatal dose and 

 the physiological effects of the two poisons were first ascertained. 



I. Minimiun Fatal Dose of Strychnia Sulphate on Cats. 



This was found to be about 1-425 of a grain to the pound. It is proba- 

 ble, however, that age and individual peculiarities produce variations in 

 the effects of this and other poisons. 



