Haynes,] 



(J06 



[March 16, 



Table V. 

 Sfioioing the Effects of Nicotin, on Cats, and the Miniimim Lethal Doie. 



85 

 66 



6 



I 



67 



68 



5 lb. 15 oz. 



8B>. 



8 lb. 





8B). 



6!) 5 n>. 6 oz. 



70 

 71 



.3Ib. 



.1 lb. » oz. 



1-18 



1-.S0 



1-60 

 1-35 



Death. 



Ueuth. 



Deutl). 

 Death. 



1-30 Recovery. 



1-20 I Recovery. 



I 



1-13 I Recovery. 



SYMPTOMS. 



Respiration slow aiiil lit bored for 3^ nu'n.. then 

 rai)idiind panting. Twitcliing of the ears. Dis- 

 inclination to move, iomin., recovering. 



The animal moved rapidly around the room 

 for [)niin. Then vomiting occurred, and was 

 followed by violent retching. He uttered in- 

 cessant cries, and walked around, but less ac- 

 tively. The rcs|)iration was slow and panting: 

 the pupils contracted. 'H)min., he walks with 

 dilliculty. having iini)erfect control over the 

 post(!rior extremities. 1 himr, recovering. 



Before the injection, the pulse wasl.jiJ, and the 

 respiration .51, a minute; the pupils were 9-20 in. 

 in diameter. L' ?;/ih., walks with great difficulty. 

 Cries out anxiously. PurLMiig and salivation. 

 Resi)iration •);'), noisy and difficult. Pupils 8-20. 

 8 miH., lay stretched out on side. Respiration 

 l.')0. Pupils 7-20; nictitating membrane drawn 

 over eye. 12 m'ni., walks with great difficulty, 

 when disturbed. Respiration extremely rapid 

 and panting. 27 min., moves head, when tail is 

 ipinched, but cannot move rest of body. 37 min., 

 'convulsive twitching of ears. 15 )iun., paralysis 

 iand complete unconsciousness. Respiration 84. 

 'Pupils 10-2<l. 12.! mill., recovering. 



Before the experiment, respiration 30; pulse 

 '1-56; i)upils 10- a). I min., respiration 30, very 

 labored. '!]/, min., respiration (iti, wliistling; 

 cried out; ears twitched ; salivation. 4 /;<//(., res- 

 ^piration 144; pupils 4-2t); violent retching, purg- 

 'ing. The aninuil lay apparently powerless, 

 but moved, though with great difficulty, when 

 Idisturbed ; the extremities weretiuite rigid. No 

 convulsive movements were apparent, except 

 [in the ears, but all the muscles ^esv1ecially the 

 'masscters) could be felt rapiiUy vibrating. 12 

 \>nin., entire paralysis; legs jerked. 13 min., res- 

 ipiration (W, noiseless; slight clonic convulsion. 

 !The respiration now became more and more 

 infrequent, and finally ceased at 15 min. The 

 [heart beat five minutes longer. The pupil 

 just belore death was 8-20. 



Before the experiment, the respiration was 57, 

 the pupil 9-20. 1 viin., respiratii)n 120, panting. 

 2 7)ji'7i., lay on side; ears twitched; violent retch- 

 ing. 7 7/ii/i., respiration 45, not noisy, but very 

 laborious; jjupils S-20. 11 min.. walked a few 

 Ipaces, with great difficulty. 12 min., irregular 

 convulsions, lasting }/, minute, and ending In 

 death, through failure of respiration. The 

 heart continued to beat for a few minutes. 



Difficult resi)iration; vomiting, purging, and 

 urination; tetanic convulsions, and death at 7 

 min. 



Immediately on termination of injection, te- 

 tanic convulsionsset in, and lasted for 1 minute, 

 when the respiration ceased. 



