1877.1 ^^'^ [Haynes. 



III. Effects of the Combined Action, of Nicotin and Strychnia Sul])hate 



on Cats. 



Experiment 72. 



Strychnia Sulpli. gr. 1-293 and Nicoiin TTLl-40 were injected together 

 into a cat, weighing 1 lb. 14^ oz. The animal immediately breathed 

 noisily and with difficulty ; the ears twitched rapidly. He walked around 

 the room with great difficulty, and at 4 minutes fell over on the side con- 

 vulsed, and shortly e.Kpired. The heart continued to beat for a time after 

 respiration had ceased, and this was the case in all the subsequent experi- 

 ments. 



EXPEIIIMENT 73. 



Strychnia Sulph. gr. 1-192 and Nicotin Tn^l-20 w^ere injected together 

 into a cat, weighing 3 lbs. 5 oz. The symptoms were : rapid, noisy 

 labored respiration ; violent retching, and purging ; in 3 minutes, tetanic 

 convulsion, and in 4 min. death. Convulsive movements of the muscles 

 of the head continued for several minutes after death. 



Experiment 74. 

 Strychnia Sulph. gr. 1-288 and Nicotin TrLl-70 were injected together 

 into a cat, weighing 3 lbs. h oz. The symptoms were the same as in the 

 preceding experiment. Death occurred at 5^ minutes. 



Experiment 75. 

 Strychnia Sulph. gr. 1-130 and Nicotin TrLl-75 were injected together 

 into a cat, weighing 8 lbs. 9 oz. ^ min-, the cat walked around the room, 

 staggering; extremities stilf; respiration slow and panting. 3 min., he 

 lay motionless on the side, but was able to move slightly, if irritated. There 

 was marked reflex excitability. The resi)iration was rapid and difficult. 6 

 min., slight, momentary, clonic convulsion. The respiration now became 

 more and more feeble and infrequent, and ceased at 13 minutes. 



Experiment 76. 



Strychnia Sulph. gr. 1-74 and Nicotin 1111-40 were injected together 

 into a cat, weighing 6^ lbs. 3 )nin.. he ran around, crying anxiously. 

 The respiration was slow, panting, and labored. 4 min., he lay over on the 

 side occasionally, as if exhausted. Convulsive twitching of the ears, and 

 violent vomiting and retching, now commenced. The membrana nictitans 

 was drawn. 5^ min., he lay stretched out, motionless, on the side, but could 

 walk, though with great difficulty, when disturbed. 9 miji., clonic, suc- 

 ceeded by tetanic, convulsions set in, and caused deatli. 



Experiment 77. 



Strychnia Sulph. gr. 1-74 and Nicotin HII-'^O were injected together into 

 a cat, weighing 6 lbs. 6 oz. The usual difficulty of breathing, vomiting, 

 and prostration, ensued. The pupil was contracted. At 6^ min., feeble 

 convulsions occurred, lasted ^ minute, and were succeeded by complete 

 paralysis. Respiration ceased at 9 minutes. 



