Hiiynef".] hiJo ManOi l(f, 



E.\i'krimp:nt 7S. 

 Strycliuia Sulpli. gr. l-Uli and Nicotin TUl-O:} wen- injected together 

 into a cat, weighing 5 lbs. 3 oz. After 5 min., twitcliingof ears ; panting, 

 rapid, hxbored respiration ; contracted pupils. Tliese symptoms, together 

 witli violent vomiting, continiu'd fill 15 minutes: when, in addition, 

 marked reflex excitability was noted. 17 min., convulsive jerking, which 

 continued at intervals until 37 min., when a violent tetanic convulsion oc- 

 curred, and killed the animal. The symptoms, up to 15 win., were those 

 peculiar to Nicotin ; then ihc convulsive action of Strychnia showed itself, 

 increased, prol)al)ly, by the identical action of Nicotin. At no time was 

 there i)aralysi8 ; the dose of Nicotin was not large enough to produce this 

 symptom. 



EXPEKIM12NT.S 79, 80, 81. 



(79) A cat weighing '2 lbs. 3 oz. received Strychnia Sulph. gr. l-'.388. 

 No symptoms resulted. 



(80) The .same animal, one week afterwards, received Nicotin 1111-86. 

 The symptoms lasted about one hour, and were as follows : violent 

 vomiting, siaggering gait, ccmtracted pupils, tuiuhing of the ears, and 

 rapid, noi.sy respiration. 



(81) The same animal, one week afterwards, received, by a single in- 

 jection. Strychnia Sulph. gr. 1-288 and Nicotin Tl\l-8r.. The respiration 

 immediately became rapid and labored. In 30 seeond-t clonic convulsions 

 commenced, and lasted till death, which occurred at 2 minutes. 



Experiments 82, 83. 



(82) A kitten, weighing 1 lb. 12 oz., received Strychnia Sulph. gr. 1-384. 

 27 min., a tetanic spasm occurred, and lasted one minute. The animal 

 then lay perfectly motionless, with panting respiration, for o minutes ; and 

 afterwards rapidly recovered. 



(83) The same kitten, one Aveek afterwards, weighing 1 lb. l^i^ oz., 

 received Strychnia Sulph. gr. 1-384, together with Nicotin TT^ 1-100. After 

 1 mill., the animal breathed laboriously, and walked with difficulty. 2 

 mill., twitching of ears, violent vomiting. 3 min., respiration very labored 

 and noisy. Limbs very stifl'. Vomiting continues. 15 /«/»., convulsions, 

 somewhat tetanic ; death at 17 min. 



Experiments 84, 85. 



(84) A ca', weighing 6 lbs. 5 oz., received Stryciinia Sulph. gr. 1-96. 

 No result ensued, except slight increase of reflex excitability. 



^85) The same animal, 20 days afterwards, weighing the same, received 

 the same dose of Strychnia Suli)h., together with Nicotin Tn.1-50. The 

 respiration immediately became difficult, then panting. 8 min., twitch- 

 ing of ears. 9 min., retching. 10 min., the animal became convulsed, 

 and in this condition leaped high in the air, then ran around the room, 

 and at 11 minutes drojiped dead. 



Experiments 86, 87, 88. 

 (86) A cat, weighing (5^ lbs., received Strychnia Sulph. gr. 1-82. No 

 symptoms ensued, except temporary stiffness in walking. 



