1877.J 



G09 



[Haynes. 



(87) The same animal, one week afterward, received Nicolin 1Ttl-30. 

 The symptoms were : very difficult respiration ; twitching of the ears ; 

 vomiting and purging ; marked prostration. After 1^ hrs., the animal 

 began to recover. 



(88) The same animal, one week after the last experiment, received 

 together Strychnia Sulph. gr. 1-82 and Nicotin Vfl 1-30. After 1 min., 

 difficult respiration, and twitching of the ears. Smin., violent vomiting, 

 purging, and urination. The animal lay over on the side, breathing 

 very noisily. 12 /nin.. tetanic convulsion, and death. 



C. On Babbits. 



I. Minimum Lethal Dose of Strychnia Sulph. on Rabbits. 



This has been detei-mined by Bennett, as regards the pure alkaloid, to 

 be 1-288 of a grain to the pound. Of course, the dose of the sulphate must 

 be proportionally greater. 



II. Minimum Lethal D)se and Phijsiohgiral effect of NicDtin on Rabbit--<. 



The minimum fatal dose was found to be about 1-80 of a minim to the 

 pound, or 1-27 of a minim to a rabbit of average size (3 lbs.). The essen- 

 tial symptoms caused by Nicotin, as in the cases of cats and rats, are 

 paralysis and convulsions, with profound disturbance of respiration. 

 Vomiting does not occur ; purging and urination are not as common 

 symptoms as they are in the cat. Rabbits are generallj^ killed by a single 

 convulsion, whether caused by Nicotin or Strychnia. 



Table VI. 



S'loming tlw Eff'e is of Various Do-fes of Nicotin on Rabbitu, ani Iniirating 



the Least Fatal Dose. 



91 13 ft). 



92 

 93 



3 ft.. 

 3tt>. 



i}4 oz. 

 1 oz. 



1-18 

 1-15 



Recover J'. 

 iRecovery. 



SY.\[l'TO-MS. 



After 10 ?)ini., the animal was somewhat lan- 

 guid, and rested at full length. 1 hour, perfect 

 recovery. 



Temporary weakness. Contraction of the pu- 

 pil. 



After 10 niin, languid. After 20 min., dragged 

 hinder legs somewhat when walking. After .SO 

 win., cea.sed to drag hinder legs, but walked as 

 if they were somewhat stilf. Pupil contracted. 



Temporary prostration, contraction of pupil. 



After 3 min., languid. The posterior extremi- 

 ties were dragged somewhat in walking, tlien 

 were moved altogether, as if they were stiff. 

 Pupils contracted. 15 min., the animal moved 

 around in a small circle. Tliere were jerking 

 movements of the body, which lasted a few 

 seconds, and were succeeded by extreme pros- 

 tration, without actual paralysis. After 45 miti., 

 recovering. 



