Haynes.) t)lZ [March 16. 



ficult respiration ; prostration. 8 min., he lay with the extromltlefe 

 stretched out, powerless, his nose touching the ground. 1 hour, convul- 

 sive jerking. lQmi7i., tetanic convulsion. 71 min., brief clonic convul- 

 sion . Recovery. 



EXPEUIMENTS 118, 119, 120. 



(118) A rabbit, weigliing 3 lbs. Hi oz., received Strychnia Sulph. gr. 

 1-77, with no effect. 



(119) The same animal, received Nicotln TlfLl-30, with the same effect 

 as in Experiment 113. 



(120) One week after, the above-mentioned doses were given together 

 to the same animal. For 22 luin., nothing was noted, except difficult loco- 

 motion, and prostration. Then two clonic convulsions occurred, in quick 

 succession. 30 min., clonic convulsion. 31 min., tetanic convulsion, and 

 death. 



D. On Dons. 



Effects of the Combined Action of Nicotin and Strychnia Sulphate on Dogs. 



EXPEUIMKNT 121. 



A dog, weighin.Li' 2 lbs. 3 oz., received Strychnia Sulph. gr. 1-96. After 

 12 min., the only s3'mptom noticed was stiffness in walking. Nicotin TU 

 1-400 was now given ; immediately, the stiffness of the extremities became 

 so marked that it was almost Impossible for the animal to walk. He lay 

 down on his side, and, at 14 7nin., had a violent clonic convulsion, lasting 

 1^ minute. At 15^ min., Nicotin 1111-400, was again injected. The 

 animal continued to lay on the side powerless ; the respiration became 

 more and more feeble ; there was convulsive twitching of the body ; and 

 death ensued, at 24 min. 



Experiment 122. 



A dog, weighing 4^ lbs., received Strychnia Sulph. gr. 1-72. 3 min., no 

 symptoms. Nicotin Til 1-400 was given. 6 mill., respiration labored,, 

 panting. 9 tnin., he is very stiff ; respiration the same. Nicotin Til 1-400 

 was again injected. 11 min., irregular convulsions, during which Nicotin 

 TTl 1-400 was injected. The convulsion ceased at the 12ih min., but the 

 iiiiimul still lay extended on the side, the respiration became less and less 

 frequent, and ceased at the lith min. 



ExPEniMENT 123. 

 A dog, weighing GA lbs., received Strychnia Sulph. gr. 1 32. (5 min., no 

 symptoms. Nicotin TTLl-200 was now injected. The respiration imme- 

 diately became somewhat labored. 13 min., tetanic convulsion. Nicotin 

 TTtl-200 injected. Immediately after the injection, a second tetanic con- 

 vulsion occurred ; shortly afterwards, a third. 16^ min., death. 



EXPEUIMENT 124. 



A dog, weighing 2^ lbs., received Strychnia Sulph. gr. 1-192, and Nico- 

 tin Till -9G, by a single injection. 30 se-ondx, slow, panting respiration. 



